Antibodies: Structure, Engineering, and Therapeutics
This learning journey is designed to provide an introduction to the structural composition of immunoglobulins, antibody engineering methods, and their therapeutic applications. Several key antibody concepts are covered including classification, discovery, clinical relevance, and immunogenicity.
Table of Contents
- An Introduction to Antibodies and their Structure
- Antibody Classes and Subclasses
- Antibody Valency and Function
- The Role and Structure of Antibody Receptors (FcRs)
- An Introduction to Antibody Engineering
- Genetic Engineering of Antibodies
- Antibody Phage Display
- The use of Antibodies for Cancer Treatment
- Antibodies for the Treatment of Cancer: Herceptin
- Monoclonal Antibodies for the Treatment of Type-1 Diabetes
- Antibodies for Transplant Tolerance
- Antibody Therapy Immunogenicity
- Autoantibodies and Autoimmune Diseases
- Can Humanised Antibodies Reduce Immunogenicity?
1. An Introduction to Antibodies and their Structure
By Dr. Mike Clark – University of Cambridge, UK
An excerpt from Antibody structure and function: antibody structure
2. Antibody Classes and Subclasses
By Dr. Mike Clark – University of Cambridge, UK
An excerpt from Antibody structure and function: antibody structure
3. Antibody Valency and Function
By Dr. Mike Clark – University of Cambridge, UK
An excerpt from Antibody structure and function: antibody function
4. The Role and Structure of Antibody Receptors (FcRs)
By Prof. Mark Cragg – University of Southampton, UK
An excerpt from The immunobiology of Fc receptors
5. An Introduction to Antibody Engineering
By Dr. Ian Wilkinson – Absolute Antibody, UK
An excerpt from Antibody engineering: beginnings to bispecifics and beyond
6. Genetic Engineering of Antibodies
By Dr. Geoffrey Hale – Chief Executive Officer of mAbsolve Ltd., UK
An excerpt from Therapeutic antibodies
7. Antibody Phage Display
By Dr. Andre Frenzel – YUMAB GMBH, Germany
An excerpt from Phage display for generating monoclonal antibodies
8. The use of Antibodies for Cancer Treatment
By Prof. Mark Cragg – University of Southampton, UK
An excerpt from Monoclonal antibodies in haemato-oncology
9. Antibodies for the Treatment of Cancer: Herceptin
By Prof. Mark Greene – University of Pennsylvania, USA
An excerpt from Monoclonal antibodies and the ErbB system in human cancer
10. Monoclonal Antibodies for the Treatment of Type-1 Diabetes
By Dr. Robert Hilbrands – Brussels Free University, Belgium
An excerpt from Antibodies to control or prevent type 1 diabetes
11. Antibodies for Transplant Tolerance
By Prof. Luis Graca – University of Lisbon, Portugal
An excerpt from Tolerance induction to clotting factors with monoclonal antibodies
12. Antibody Therapy Immunogenicity
By Prof. Herman Waldmann – University of Oxford, UK
An excerpt from The immunogenicity problem in antibody therapy
13. Autoantibodies and Autoimmune Diseases
By Dr. Luís Eduardo Coelho Andrade – UNIFESP, São Paulo, Brazil
An excerpt from Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes
14. Can Humanised Antibodies Reduce Immunogenicity?
By Dr. Geoffrey Hale – Chief Executive Officer of mAbsolve Ltd., UK
An excerpt from Therapeutic antibodies