Antibodies: Basics, applications & advanced concepts
This learning journey offers an overview of antibodies, covering their structure, classes, and subclasses, and their role in the immune system. It explores the therapeutic applications of antibodies, including their use in cancer, Type-1 diabetes, and transplant tolerance, while also addressing advanced concepts like antibody engineering, humanization, and the role of autoantibodies in autoimmune diseases.
Table of Contents
- An Introduction to Antibodies and their Structure
- Antibody Classes and Subclasses
- Antibody Valency and Function
- The Role and Structure of Antibody Receptors (FcRs)
- An Introduction to Antibody Engineering
- The use of Antibodies for Cancer Treatment
- Monoclonal Antibodies for the Treatment of Type-1 Diabetes
- Antibodies for Transplant Tolerance
- Autoantibodies and Autoimmune Diseases
- Can Humanised Antibodies Reduce Immunogenicity?
1. An Introduction to Antibodies and their Structure
By Dr. Mike Clark – University of Cambridge, UK
An excerpt from Antibody structure and function: antibody structure
2. Antibody Classes and Subclasses
By Dr. Mike Clark – University of Cambridge, UK
An excerpt from Antibody structure and function: antibody structure
3. Antibody Valency and Function
By Dr. Mike Clark – University of Cambridge, UK
An excerpt from Antibody structure and function: antibody function
4. The Role and Structure of Antibody Receptors (FcRs)
By Prof. Mark Cragg – University of Southampton, UK
An excerpt from The immunobiology of Fc receptors
5. An Introduction to Antibody Engineering
By Dr. Ian Wilkinson – Absolute Antibody, UK
An excerpt from Antibody engineering: beginnings to bispecifics and beyond
6. The use of Antibodies for Cancer Treatment
By Prof. Mark Cragg – University of Southampton, UK
An excerpt from Monoclonal antibodies in haemato-oncology
7. Monoclonal Antibodies for the Treatment of Type-1 Diabetes
By Dr. Robert Hilbrands – Brussels Free University, Belgium
An excerpt from Antibodies to control or prevent type 1 diabetes
8. Antibodies for Transplant Tolerance
By Prof. Luis Graca – University of Lisbon, Portugal
An excerpt from Tolerance induction to clotting factors with monoclonal antibodies
9. Autoantibodies and Autoimmune Diseases
By Dr. Luís Eduardo Coelho Andrade – UNIFESP, São Paulo, Brazil
An excerpt from Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes
10. Can Humanised Antibodies Reduce Immunogenicity?
By Dr. Geoffrey Hale – Chief Executive Officer of mAbsolve Ltd., UK
An excerpt from Therapeutic antibodies