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Printable Handouts
Navigable Slide Index
- Introduction
- Introduction to nanotechnology
- Nanotechnology in cancer therapy
- Treatment of cancer
- Nanotechnology-based strategies for cancer therapy
- Nanoparticles can target cancer cells via active or passive targeting
- Why controlled drug delivery?
- Biodegradable polymers
- Recent efforts on cancer and insulin therapy
- Preparation methods
- SEM images of microspheres
- Impact of pH on 5-FU release
- Attachment of deoxycholic acid to PEG/PHB
- NPs of PHB for 5-FU targeting to colon
- Ultra-small nanoparticles of PHB-PEG-folic acid block copolymers (1)
- Ultra-small NPs of PHB-PEG-folic acid block copolymers (2)
- Development of NPs of varying sizes
- DSC, TGA and XRD curves
- Hyperspectral imaging (1)
- NPs are taken up by cancer cell lines (1)
- NPs are taken up by cancer cell lines (2)
- Oral administration of Rh123 loaded NPs
- Colon targeting of 5-FU by PEG cross-linked chitosan MPs enteric coated with CAP
- Why is coating necessary?
- Formation of agglomerates after CAP coating
- Oral insulin therapy
- Hydrogel polymers for insulin delivery
- DOCA conjugated PHB-PEG block copolymer nanoparticles (1)
- DOCA conjugated PHB-PEG block copolymer nanoparticles (2)
- DSC/TGA curves and particle size distribution
- Loading of insulin
- Hyperspectral imaging (2)
- Cheek cells after NP incubation
- Colon cells after NP incubation
- Blood glucose level experiments
- Pharmacokinetic data of insulin
- Plasma insulin levels over time
- Summary of NPs for insulin delivery
- Other NP formulations for insulin delivery
- Movement of orally administered insulin NPs
- Concluding remarks
- Acknowledgments
Topics Covered
- Nanotechnology
- Cancer therapy
- Insulin therapy
- Nanoparticles
- Polymer chemistry
- Drug design
- Coated vs. uncoated drugs
- Controlled drug delivery
Links
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Therapeutic Areas:
Talk Citation
Aminabhavi, T. (2021, October 31). Nanotechnology in cancer and insulin therapy [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/TMFA8318.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Tejraj Aminabhavi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Methods
Transcript
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0:00
Nanotechnology in cancer and insulin therapy.
I am Professor Tejraj Aminabhavi, I did my PhD at the University of Texas, Austin USA.
I've published 849 papers in the nanotechnology field, I have an h-index of 98,
I have published three US patents, I am the editor of Chemical Engineering Journal.
I have expertise in polymer development, for drug delivery membrane science and wastewater treatment.
0:32
Nanotechnology is a ground-breaking field to explore and exploit numerous nanosystems,
that can offer multiple potential therapeutic benefits for the treatment of many chronic human diseases,
by site/target-specific delivery of therapeutics.
Recently, there have been a number of outstanding nanosystems developed for efficient drug delivery.
These nanosystems have been reported for the delivery of various drugs,
such as CNS drugs, cardiovascular drugs, antibiotics, anticancer drugs,
antiviral drugs, proteins, insulin, and so on.
These can be delivered through different routes of administration,
such as oral, nasal, ocular, transdermal, intravenous, and so on.
These systems are employed for targeted drug delivery to the brain, cancer, as well as colon delivery.
1:39
Recently, due to effective drug delivery, and preciseness of tumor sites or the microenvironment,
targeted drug delivery approaches have gained much importance for tumor metastasis therapy.
In fact, conventional treatments for metastasis therapy have many adverse effects,
since they kill carcinogenic cells but also healthy cells.
Tumor vasculature and angiogenesis has greatly depended upon growth and metastasis in tumors,
so various nanocarrier-based delivery approaches for targeting tumor vasculature are used
for the treatment of tumor metastases, and associated lesions.
Targeted drug delivery can overcome limitations and adverse effects associated with conventional therapies.