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1. Introduction
2. Topics to cover
3. SLE - apoptotic cells clearance deficiency
4. Apoptotic cells clearance deficiency - conclusion
5. SLE - introduction
6. Woman with SLE
7. SLE - predispositions
8. SLE clinical characteristics
9. SLE etiology
10. SLE pathology
11. Introduction - apoptotic and necrotic cell death
12. Apoptosis and necrosis
13. Introduction - clearance of dying cells
14. Dying cells: source of autoantigens
15. Apoptotic cell clearance
16. Necrotic cell clearance
17. Apoptotic cell
18. Process of apoptosis - ligand recognition
19. Process of apoptosis - impaired ligand recognition
20. Phagocytosis - mediating ligands and receptors
21. Apoptosis does not evoke inflammation
22. Introduction - anti-inflammatory effects of apoptosis
23. Example with monocytes
24. AxV reverts anti-inflammation
25. AxV reverts humoral immune suppression
26. Balance of inflammation
27. Balance of inflammation:anti-inflammatory signals
28. Secondary necrosis reverses anti-inflammation
29. Apoptotic cells in cultured PBMC of SLE patients
30. PBMC culture
31. Apoptotic cells in germinal centers of SLE patients
32. Clearance deficiency in germinal centers (GC)
33. Germinal centers of SLE patients
34. Clearance deficiency in morphometry - cell count
35. Clearance deficiency in morphometry - cell size
36. Clearance deficiency in GC: confocal
37. B cell maturation - healthy donor
38. Apoptosis of mutated B cells - healthy donor
39. ANA-reactive B cells - healthy donor
40. ANA-reactive B cells - SLE patient
41. Apoptotic trash causes autoimmunity
42. Apoptotic trash triggers anti-dsDNA reactivity
43. Implications for anti-dsDNA
44. Binding specificity of 33.C9 variants
45. The 33C9 Ab gained its activity in the GC reaction
46. High affinity Abs generated in GC
47. Apoptotic cells accumulate in CLE skin
48. Apoptotic cells accumulate in CLE skin - TUNEL
49. Apoptotic cells accumulate in CLE - caspase 3
50. Apoptotic cells accumulate in CLE - cell count
51. Humoral factors contribute to the clearance
52. NHD-derived macrophages trigger cell clearance
53. Clearance deficiency in SC derived phagocytes
54. Stem cells in culture
55. Stem cells cell cycle
56. Stem cells phagocytosis and adherence
57. Summary stem cells phagocytosis and adherence
58. Animal models for clearance deficiency - intro
59. Knockout mice with phagocytosis defects
60. Conclusion
61. Support
62. Coworkers

Topics Covered

• Anti-inflammatory and immunosuppressive effects of apoptotic cells
• Autoimmune disease and clearance of dying cells
• Clearance deficiency of apoptotic cells
• Germinal centre tingible body macrophage deficiency
• Model for the generation of nuclear autoimmunity
• Annexin V as adjuvans for irradiated tumor cells

Links

Series:

• Apoptosis

Categories:

• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Martin Herrmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.