Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Introduction to B cells
3. Innate-like B cells (1)
4. Innate-like B cells (2)
5. Innate and adaptive mechanisms
6. Innate-like B cells are similar to innate-like T cells
7. Mouse B-1 cells
8. The origin and maturation of B cells
9. T cell dependent antibody responses
10. Germinal centers
11. Innate-like B cells have multiple characteristics
12. Characteristics of Innate-like B cells
13. Molecular targets of the innate immune system
14. B1a antibody response to phosphorylcholine (PC)
15. PC is a major component of organisms
16. B1a subset
17. Development of innate-like lymphocytes
18. TEPC15Id expressing B cells (1)
19. TEPC15Id expressing B cells (2)
20. Some clones depend on TdT activity
21. B1B + MZ
22. Low affinity and high avidity antibodies
23. Conserved antigens on a variety of organisms
24. Chitin
25. Monoclonal antibodies to GlcNAc bind chitin
26. Alpha 1-3 glucans
27. Sialyl-lacto-N-tetraose
28. Antibodies to Aspergillus fumigatus
29. The spleen: largest encapsulated lymph organ
30. Special characteristics of the spleen
31. Association between asplenia and OPSI
32. A ruptured spleen is very dangerous
33. The marginal zone forms an interface
34. Anatomy of the mouse spleen
35. Histological analysis of the mouse spleen
36. Fluorescent-labeled bacteria to mouse spleen
37. MZ B cells respond to blood-borne organisms
38. Immune response in anti-PC Tg mice
39. Innate-like B cells and protection against infection
40. Human innate-like B cells
41. Innate-like B cell derived antibodies: self-reactive
42. Why these clones react to self antigens
43. Functions of innate B cells and their products
44. Summary
45. Acknowledgements

Topics Covered

• Introduction to B cells
• Innate-like B cells
• Origin and function of innate-like B cells
• Targets of Innate-like B cell derived antibody
• Anatomy of Innate-B cell organ distribution
• Human Innate-like B cells and possible clinical applications

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Prof. John F. Kearney has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.