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1. Intro slide
2. Motor neurone diseases
3. MND: a neurodegenerative disease
4. Definition
5. Synonyms
6. Epidemiology
7. Age of onset
8. ALS: spinal onset
9. Relevant investigations
10. ALS: bulbar onset
11. Relevant investigations
12. Progressive Muscular Atrophy
13. Primary Lateral Sclerosis
14. Regional variants
15. Diagnosis
16. El-Escorial Criteria
17. Clinical utility of El-Escorial criteria
18. Conveying the diagnosis
19. Clinical progression
20. Natural history of MND/ALS
21. Prognostic guides
22. One disease or many?
23. Molecular neuropathology: Bunina bodies
24. Molecular neuropathology: skein-like inclusions
25. Hyaline inclusions
26. Dystrophic neurites
27. Familial ALS/MND
28. SOD1 associated ALS/MND
29. Clinical follow up
30. The Care Team
31. Drugs treatments
32. Evidence for clinical benefit with riluzole
33. Human therapeutic trials
34. Treatable symptoms
35. Enablement
36. Weight loss
37. Nutritional management
38. Assessment of respiratory function
39. Respiratory care
40. ALS as a multisystem disease
41. Cognitive impairment
42. Neuropathology of MND dementia
43. Key points
44. The future

Topics Covered

• Main clinical subtypes of MND
• Neuropathological features
• Molecular pathology and prognosis
• Multidisciplinary management
• Effectiveness of current drug treatments

Links

Series:

• Neurodegenerative Diseases

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Kevin Talbot has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.