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1. Introduction
2. Modulation of intrinsic neuronal excitability
3. Synaptic integration and AP firing
4. Synaptic integration
5. Fast synaptic transmission
6. Ionotropic receptors
7. Synaptic integration (2)
8. Neuromodulation
9. Metabotropic receptors
10. Acetylcholine system
11. Synthesis of acetylcholine
12. Serotonin system
13. Synthesis of serotonin
14. Dopamine system
15. Synthesis of dopamine
16. Norepinephrine system
17. Synthesis of norepinephrine
18. Metabotropic receptors (2)
19. Common actions of neuromodulators
20. Modulation of intrinsic neuronal excitability
21. Synaptic integration - intrinsic excitability
22. Modulation of intrinsic neuronal excitability
23. Modulation of firing by activation of GPCRs
24. Modulation of hippocampal neurons by ACh
25. Modulation of hippocampal neurons by dopamine
26. Modulation of hippocampal neurons by NE
27. cAMP mimics the effects of norephinephrine
28. Signaling pathways for norepinephrine
29. Modulation of hippocampal neurons by Ach (2)
30. Phorbol esters mimic the effects of ACh
31. Signaling pathways for acetylcholine
32. Modulation of neocortical pyramidal neurons
33. Modulation of Purkinje cells by serotonin
34. Differential modulation of inhibitory interneurons
35. Bullfrog sympathetic ganglion
36. Stomatogastric ganglion
37. Common signaling pathways for GPCRs
38. Modulation by other mechanisms
39. Synergistic effects of GPCR activation
40. Signal transduction pathways not via G proteins
41. GPCR-dependent and independent signaling (1)
42. GPCR-dependent and independent signaling (2)
43. Activity dependent modulation (1)
44. Activity dependent modulation (2)

Topics Covered

• Synaptic integration and action potential firing
• Neuromodulation
• Modulation of firing by activation of GPCRs
• Modulation by other mechanisms
• Targets of modulation
• Modulation activity in the thalamus
• Long-term plasticity of intrinsic excitability -Local control of excitability

Links

Series:

• Ion Channels

Categories:

• Biochemistry
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on April 7, 2011

Financial Disclosures

• Prof. Nelson Spruston has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.