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1. Introduction
2. Introduction- Prof. George Calin
3. Central dogma of molecular oncology
4. 13q14.3: one region and two types of genes
5. MicroRNA - size doesn't matter
6. Small RNAs make a big splash
7. How many RNAs are enough for what?
8. HE-miRNA mediated control of haematopoiesis
9. Mir-155 inhibited generation of colonies
10. Alterations of miRNAs are found in all tumor types
11. MiR15a and miR16-1 in B-CLL
12. Microarray of CLL cells
13. MiRNA expression signature in solid cancers
14. A miRNA signature of hypoxia
15. MiRNA in pancreatic endocrine and acinar tumors
16. The combinational "in cascade" model
17. MiRNAs an oncogenes and tumor suppressors (1)
18. MiRNAs an oncogenes and tumor suppressors (2)
19. MiR15 and miR16 induce apoptosis
20. MiR15 and miR16 target multiple genes
21. MiR29 family and its role in lung cancer
22. MiRNA profiling as diagnostic and prognostic tools
23. Unique miRNA signature in CLL progression
24. Tcl1 expression regulated by miR-29 and miR-181
25. Unique miRNA signature in lung cancer diagnosis
26. MiRNA expression in breast cancer
27. MiRNA and breast cancer metastases
28. MiR21 expression in tumors and chemotherapy
29. MiRNA alterations cause cancer predispositions
30. Cancer predispositions
31. Germline abnormalities in miR15a/16-1 transcript
32. Mutation in NZB mice causes the same disease
33. Mutations in miRNA primary transcripts
34. The "field effect" of miRNA expression
35. Chromosomal positions of tumor susceptibility
36. Variations in promoters in "modifier" miRNAs
37. MiRNAs - the missing link in cancer predisposition
38. MicroRNAs as new therapeutic targets and drugs
39. Principles of miRNA gene therapy
40. MiR15 and miR16 based gene therapy in CLL
41. Effects of miR-29s on tumorigenicity of A549 cells
42. The genome revolution is not over
43. Ultraconserved non-coding genes
44. Other ncRNAs could be associated with cancer
45. UCG expression profiles classify human cancer
46. MiRNA-ncRNA interactions
47. Non coding RNAs as oncogenes
48. Revisiting the molecular oncology dogma
49. Acknowledgment
50. Enjoy the ncRNA revolution

Topics Covered

• Central dogma of molecular oncology
• MicroRNA and messenger RNA
• Small RNAs make a big splash
• A model for HE-miRNA mediated control of human haematopoiesis
• Alterations of microRNAs are found in every type of human tumors
• MicroRNAs as oncogenes and tumor suppressors
• miR-15 and miR-16 induce apoptosis by targeting BCL2
• They target multiple apoptosis and cancer related genes
• MicroRNA-29 family
• MiRNA profiling as a new diagnostic and prognostic tool for cancer patients
• A unique miRNA signature is associated with CLL progression
• Cancer predisposition: from epidemiology to genetics
• About humans and mice: same gene, same mutation, same disease
• Mutations in microRNA primary transcripts
• The "field effect" of miRNA expression
• The missing link in cancer predisposition
• MicroRNAs as new therapeutic targets and new drugs
• Principles of miRNA-based gene therapy and in vivo inhibition of miRNA in cancer cells
• Ultraconserved non-coding genes: the new chapter of the textbook
• A never ending revolution: other ncRNAs could be associated with cancer
• UCG expression profiles classify human cancers
• miRNA-ncRNA interactions
• Non-coding RNAs as oncogenes

Links

Series:

• Microarrays

Categories:

• Cancer
• Cell Biology
• Genetics & Epigenetics
• Methods

Therapeutic Areas:

• Oncology

Talk Citation

Calin, G. (2009, March 30). Genome-wide profiling of microRNAs: from scientist benchside to patient bedside [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/FYLW4969.
Export Citation (RIS)

Publication History

• Published on March 30, 2009
• Archived on February 25, 2021

Financial Disclosures

• Prof. George Calin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.