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0:00
Welcome. My name is Paul Boylan.
I am faculty at
the University of
Oklahoma Health Sciences
College of Pharmacy
in Oklahoma City.
Today we'll be
discussing the topics of
Theophylline and
Anti-Leukotrienes for
the Treatment of Airway
Allergic Disorders.
0:18
This presentation will
occur in three parts.
Our intro and Part I will
cover airway inflammation.
The second component
will discuss
the medication theophylline in
the class of medications
the methylxanthines.
Then Part III we'll
discuss another
medication, montelukast,
one of the leukotriene
receptor antagonists
and updated evidence
on these medications.
0:44
Without further ado,
let's jump into
Part I and discuss
airway inflammation.
0:50
Before we take a deep dive
into airway immunology,
we should have an
introductory discussion
on essential terms that
you must be familiar with.
There are three terms that
I've placed for
you on this slide;
leukocytes, cytokines,
and interleukin.
Many of you are
likely familiar with
the stem cell line that
stem cells differentiate into
myeloid and lymphoid lines.
Common myeloid cells
include red blood cells,
platelets and then
those granulocytes.
The most common
granulocytes that
we'll talk about
throughout this course
of presentations will be
the eosinophils
and the basophils.
Compared to the lymphoid line
within the adaptive
immune response,
those will include our
B and T lymphocytes.
The lymphocytes and
the granulocytes
both together make
up the leukocytes.
These are blood cells
that are made in
the marrow and then circulate
throughout the body.
Not to be confused
with cytokines.
Although leukocytes
and cytokines
both contain that cyto prefix.
You will see that cytokines
are a little bit different.
These are smaller-sized
proteins and these are
communication
proteins that help to
network and transmit signals
between different cells.
The last component herein
will be the interleukins
and interleukins are a
subtype of the cytokines.
These interleukins are cytokines
that are made by
those leukocytes.
It could be any of
those that we've
previously discussed,
the granulocytes or
the lymphocytes,
and those cytokines will
then act on one another to
serve as messengers between
these inflammatory mediators.
