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Hello. I'm Dawn Buse.
I'm a clinical professor at
Albert Einstein
College of Medicine in
the Department of Neurology
and a licensed psychologist.
In this presentation, I will be
talking about "Migraine
Comorbidities".
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Here are my disclosures.
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Let's start by reviewing
the definitions or
differences between
comorbidities
versus concomitant conditions.
Comorbidity is the greater
than chance association
between two conditions or
diseases in the same individual.
There may also be clusters of
comorbidities known
as multimorbidities,
whereas concomitant
conditions occur together in
the same individual with
the same frequency that would
be predicted by chance.
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Comorbidity is important in
both clinical care as well
as scientific understanding
of disease for many reasons.
Comorbidities may
complicate diagnosis,
and diagnostic
parsimony may lead
to underdiagnosis
or misdiagnosis.
Comorbidities may also
inform and limit treatment.
For example, there may
be therapeutic two-fers
or treating two diseases
with one treatment,
whereas there may also
be limitations such as
contraindications introduced by
certain diseases
or medical events.
Comorbidities help
predict prognosis.
They help us know
the natural history,
natural course of a disease.
In the case of migraine,
some comorbidities are known
risk factors for
disease progression,
moving from episodic to
chronic migraine or moving in
a higher frequency
bracket from low
to moderate to high
frequency episodic migraine.
Also, comorbidities help us
identify endophenotypes,
especially the multimorbidity
constellations,
and they can facilitate
genetic research as well
as a greater understanding
of patient phenotypes.
Cormorbidity certainly
contributes to
disease burden for
the individual.
They're associated with worse
health-related quality of life,
greater economic
impact on many levels,
including to the individual as
well as society and
the health system.
