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1. Introduction
2. E. faecalis can adapt to many different situations
3. Adaptation can be short-term or longer term
4. Sex-pheromone plasmids and conjugation
5. A genetic map of the pCF10 plasmid
6. Main points of the talk
7. Original 1-way signaling model is overly simple
8. Pheromone synthesis and control circuits (1)
9. Pheromone synthesis
10. The PrgY/TraB family tree
11. Model for PrgY function
12. Part I -summary: action from the membrane out
13. Early regulatory events in pheromone induction
14. PrgX function in PrgQ transcription control
15. Structure of PrgX/cCF10 vs. PrgX
16. Structure of PrgX/iCF10 - C-terminus
17. Integration of structures into working models
18. The remaining issues with the looping model
19. Main points
20. Plasmid pCF10
21. In vivo plasmid transfer
22. Induction of pCF10 transfer by plasma
23. Pheromone synthesis and control circuits (2)
24. PrgB expression increases virulence
25. Evolution and "kluging"
26. Conclusion
27. Acknowledgements
28. References (1)
29. References (2)

Topics Covered

• Overview of the evolutionary and medical significance of plasmids in E faecalis
• Overview of cell-cell signaling and plasmid transfer
• The sex pheromone system
• Pheromone production and control plasmid pCF10 as a model for pheromone-controlled plasmid transfer
• Mechanism of pheromone induction
• Multiple roles for pheromone induction
• Maintenance of complexity in evolution

Links

Series:

• Biology and Significance of Plasmids

Categories:

• Methods
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Dunny, G. (2008, January 28). The pCF10-encoded pheromone response: cell-cell signaling, complexity and evolution [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 4, 2025, from https://doi.org/10.69645/LEXM1474.
Export Citation (RIS)

Publication History

• Published on January 28, 2008
• Archived on May 28, 2025

Financial Disclosures

• Prof. Gary Dunny has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.