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Visualization of transcription factor interactions in living cells
Other Talks in the Series: Epigenetics, Chromatin, Transcription and Cancer
The basal transcription machinery for RNA polymerase II
- Prof. H. T. Marc Timmers
- University of Utrecht, The Netherlands
The Myc transcription factor network
- Prof. Robert N. Eisenman
- Fred Hutchinson Cancer Research Center, USA
Hello, my name is Tom Kerppola. I am a Howard Hughes Medical Institute investigator and professor of biological chemistry at the University of Michigan Medical School. In my presentation I will discuss transcription factor interactions. I will especially focus on new methods developed in my laboratory for the visualization of protein interactions in living cells. Since I will not have time to discuss all details in my presentation, I have included a link to our website. And I invite you to go to the website to look for additional information.
I will start my discussion by introducing the importance of studies of protein interactions for understanding of biological regulatory specificity. All cells are constantly responding to stimuli from their environments. The specificity of these responses is determined by protein interactions at many different levels. Extracellular stimuli induce interactions between proteins at the membrane, including receptors and other proteins. These interactions produce signals that induce additional interactions among intercellular signal transduction proteins. The signal transduction network induces transcription factor interactions, both off DNA and upon assembly at specific regulatory elements. These interactions in turn produce changes in the expression of specific target genes. Thus, cells respond to their environment by altering protein interactions.