• Introduction
• 26 min
  1. From DNA to proteins: the multiple levels of regulation

  • Prof. Panagiotis Tsonis
• Chromatin and DNA
• 44 min
  2. Chromatin architecture and alterations in the control of gene regulation

  • Prof. Jeffrey Hansen
• 43 min
  3. Nucleosome dynamics and remodeling

  • Prof. Jonathan Widom
• 25 min
  4. DNA replication

  • Prof. Smita Patel
• Transcription
• 47 min
  5. Nucleotide dependent functioning of bacterial enhancer binding proteins, activators of sigma54 RNA polymerase

  • Prof. Martin Buck
• 44 min
  6. Mechanisms of transcription: the eukaryotic pre-initiation complex

  • Prof. Michael Hampsey
• RNA (I)
• 38 min
  7. Pre-mRNA splicing

  • Prof. Timothy Nilsen
• 60 min
  8. Self-splicing intron RNAs: ribozymes, parasites and agents of genomic change

  • Prof. Anna Marie Pyle
• 47 min
  9. Polyadenylation of mRNA precursors: mechanism, regulation and connections with other cellular processes

  • Prof. James Manley
• 46 min
  10. mRNA capping

  • Prof. Aaron Shatkin
• RNA (II)
• 40 min
  11. Nonsense-mediated and Staufen1-mediated mRNA decay: related pathways of post-transcriptional control in mammalian cells

  • Prof. Lynne Maquat
• 40 min
  12. The silent revolution: an introduction to gene regulation by microRNAs

  • Dr. Frank Slack
• 50 min
  13. RNA editing: changing the code in plants, animals and parasites

  • Prof. Stephen Hajduk
• Proteins
• 18 min
  14. The principle of translation

  • Prof. Joachim Frank
• 17 min
  15. Translation initiation

  • Prof. Patrick Linder
• 47 min
  16. Elongation of protein synthesis: structural basis of the process of decoding

  • Prof. Marina Rodnina
• 40 min
  17. Elongation of protein synthesis: structural basis of the peptide bond

  • Prof. Marina Rodnina
• 44 min
  18. How do proteins fold and why?

  • Prof. Walter Englander
• 55 min
  19. Protein degradation

  • Prof. Alfred Goldberg
• Understanding Global Gene Expression
• 33 min
  20. Comparing transcriptomes of distant organisms: the comparative ENCODE resource 1

  • Prof. Mark Gerstein
• 22 min
  21. Comparing transcriptomes of distant organisms: models of gene expression 2

  • Prof. Mark Gerstein
• 47 min
  22. Protein networks and analysis of global gene expression

  • Dr. Trey Ideker
• Archived Lectures *These may not cover the latest advances in the field
• 42 min
  23. Chromatin and transcription

  • Prof. Roger Kornberg
• 40 min
  24. Nuclear organization and gene expression

  • Prof. David Spector
• 35 min
  25. Gene and protein microarrays: tools for gene discovery and function

  • Prof. Craig R. Tomlinson

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Composition of the eubacterial ribosome
3. Principle of translation
4. Elongation of the polypeptide chain
5. Role of elongation factors EF-G and EF-Tu
6. The four phases of translation
7. Initiation - sequence of events
8. Visualization of ribozome and translation process
9. Cryo-electron microscopy of single molecules
10. Transfer RNA - tRNA
11. Lock and key fit
12. The 70S ribosome
13. mRNA , tRNA and polypeptide interactions
14. The path of tRNA
15. The path of mRNA
16. Elongation factors and molecular mimicry
17. Implications of structural mimicry
18. Elongation cycle
19. Elongation cycle of protein biosynthesis
20. Highly conserved features in ribosomes
21. Tree diagram - philogeny of ribosomal RNA

Topics Covered

• Composition of the ribosome
• Principle of translation
• The four phases of translation
• Structure and function of small and large ribosomal subunits
• Role of elongation factors
• The paths of messenger RNA, transfer RNA and the nascent polypeptide
• Elongation cycle and binding positions of elongation factors
• Decoding, peptidyl transfer and translocation
• Phylogenetic conservation of ribosomal architecture

Links

Series:

• From DNA to Proteins

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Joachim Frank has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.