• Special Designs
• 46 min
  1. Family-based association tests: introduction

  • Dr. Christoph Lange
• 29 min
  2. Family-based association tests: FBAT testing strategies for large-scale association studies

  • Dr. Christoph Lange
• 37 min
  3. Two-stage genome-wide association designs

  • Dr. Andrew Skol
• Special Populations
• 40 min
  4. Admixture mapping

  • Dr. Paul McKeigue
• Whole-Genome Studies: Types of Data
• 34 min
  5. QTL association mapping

  • Prof. Bruce Weir
• 50 min
  6. Adjusting for population structure in genetic association studies

  • Prof. David Balding
• Whole-Genome Studies 2: Methods
• 47 min
  7. Whole-genome association studies: practical advice and considerations

  • Dr. Mike Weale
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  8. Family-based association tests: FBATs for various data types

  • Dr. Christoph Lange
• 44 min
  9. Choosing between family-based and population-based association designs

  • Dr. Ren-Hua Chung
• 54 min
  10. Use of isolated populations: pitfalls and potential

  • Dr. Leena Peltonen
• 40 min
  11. Information on untyped variation in genome-wide association studies

  • Dr. Dan Nicolae
• 37 min
  12. Detecting multiple associations in genome-wide studies

  • Prof. Frank Dudbridge
• 30 min
  13. Genome scanning by composite likelihood

  • Dr. Andrew Collins
• 41 min
  14. Multistage sampling for genetic studies

  • Prof. Robert Elston
• 39 min
  15. Screening large-scale association study data: exploiting multi-gene interactions with random forests

  • Dr. Kathryn Lunetta
• 43 min
  16. A survey of multi-locus methods for analysis of large SNP datasets

  • Mr. A. Geert Heidema
• 34 min
  17. Sequential analysis methods in genomic scans

  • Prof. Michael Province

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Association mapping for QTLs
3. Quantitative traits
4. Two-allele models
5. Trait mean and variance
6. QTL models
7. Traditional model
8. Traditional model moments
9. Fisherian model
10. Fisherian model moments
11. Zeng model
12. Marker loci (1)
13. Marker loci (2)
14. Marker-QTL frequencies
15. Marker-based moments
16. Traditional model: marker-based representation
17. Fisherian model: marker-based representation
18. Zeng model: marker-based representation
19. Regression of trait on marker
20. Marker-trait frequencies
21. Marker data
22. Trait data
23. Marker-trait data
24. Regression coefficients
25. Marker-trait correlation
26. Regression ANOVA
27. Testing procedure
28. Power of test (1)
29. Power of test (2)
30. Alternative marker variable (1)
31. Alternative marker variable (2)
32. Marker conditioning on trait
33. Case-only Hardy-Weinberg
34. Case-control comparisons (1)
35. Case-control comparisons (2)
36. Extensions
37. References (1)
38. References (2)

Topics Covered

• QTLs affect continuous traits
• Generally mapped from pedigree or family data
• Genome-wide association studies extended to QTLs
• Alternative models for genetic values
• Regress trait values on genetic markers
• Power of regression tests
• Case-control tests when QTL governs probability of affection
• Case-only Hardy-Weinberg tests

Links

Series:

• Genetic Epidemiology II

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Bruce Weir has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.