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Navigable Slide Index

1. Introduction
2. FBAT testing strategies for large-scale studies
3. Genome-wide association studies
4. Using the same data set for screening and testing
5. General concept proposed by Laird and Lange
6. Application to family-based association tests (1)
7. Application to family-based association tests (2)
8. The conditional mean model
9. The conditional mean model: assumptions
10. The conditional mean model: notation
11. The FBAT-statistic
12. Genetic model under the alternative hypothesis
13. The concept of the conditional mean model
14. The variables of the conditional mean model
15. The screening technique for multiple markers
16. PBAT's screening techniques for multiple SNPs
17. The three steps of the screening technique
18. Framingham heart study
19. Genome-wide association results
20. BMI in Framingham heart study
21. Replication (recessive model)
22. Important observations from Herbert et al (2006)
23. Key to success in Herbert et al. (2006)
24. Summary of the approach
25. Extensions
26. Software implementation

Topics Covered

• Genome-wide association studies
• Using the same data set for screening and testing
• The conditional mean model
• The FBAT-statistic
• Genetic model under the alternative hypothesis
• The concept of the conditional mean model
• The screening technique for multiple markers
• PBAT's screening techniques for multiple SNPs
• The 3 steps of the screening technique
• The Framingham heart study
• Replication (recessive model) from other studies
• Important observations from Herbert et al. (2006)
• Summary of the approach
• Extensions
• Software implementation

Links

Series:

• Genetic Epidemiology II

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Lange, C. (2007, October 1). Family-based association tests: FBAT testing strategies for large-scale association studies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 29, 2025, from https://doi.org/10.69645/MUMO8918.
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Publication History

• Published on October 1, 2007
• Archived on May 28, 2025

Financial Disclosures

• Dr. Christoph Lange has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.