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Navigable Slide Index
Topics Covered
- Definition of Patient and Public Involvement (PPI)
- PPI in clinical trials
- PPI and equality, diversity and inclusivity
- PPI members
Talk Citation
Hackshaw, A. (2025, March 31). Patient and public involvement [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 27, 2025, from https://doi.org/10.69645/RCPW6191.Export Citation (RIS)
Publication History
- Published on March 31, 2025
Financial Disclosures
- There are no commercial/financial matters to disclose.
Other Talks in the Series: Key Concepts: Introduction to Clinical Trials
Transcript
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0:00
Hello. I'm Allan Hackshaw
and I'm going to give
a brief overview about
the patient and
public involvement
features of clinical trials.
0:11
In previous sessions,
I talked about how
trials are designed
and analyzed. How they're
conducted, and the
ethical and regulatory
considerations.
But here I'm going to give
a very brief outline of how
patients or participants can
be involved in the studies.
This is a key feature of
modern clinical trials now
there's enough patient
or public involvement.
I'm going to give
an outline of why
it's useful and how
it can be done.
0:37
What is patient and
public involvement?
For many decades,
clinical trial concepts and
designs were just developed by
a group of health
professionals or
clinicians on a topic they
thought was most important
for society or for patients.
But over the last
several years now,
the involvement of patients or
public participants is
much more integrated and
they can be incredibly
useful not only in terms
of designing a study
but also trial conduct.
It could involve members of
the general public
that represent
the target trial group,
i.e., people with a
particular disorder.
It could be current
or past patients
with a disorder of
interests, carers,
patient advocacy groups or
charities that represent people
with that disorder of
interests. There's all
sorts of sources that we
can get these people from.
1:27
Why is PPI useful?
They can be incredibly
helpful in terms of
comments on whether
the new intervention
is going to be
appealing to them.
It's not uncommon that a
group of health
professionals think that
new intervention is
going to be appealing to
patients and when they try
it out, actually, isn't.
Knowing that upfront
helps hugely with
delivering the study or
even adapting
intervention accordingly.
PPI input can help
the trial design
so they can say if there are too
many extra clinic visits or
assessments or if being
involved in the trial
costs them too much money
because they have to
attend the centre.
They can help to create the
participant information
sheet materials and how it's
worded and they can
help solve problems
with trial conduct such
as low recruitment.
They can help interpret
the trial findings at the
end in a simple way that
can be sent to all
trial participants
and to disseminate
the information.
Many funders of
trials now want to
see significant PPI
input as part of
the grant application
because they want to see
integral involvement
between the PPI members
and the health professionals.
An extension of PPIE