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0:00
Hello. I'm Allan
Hackshaw and I'm going
to give a short overview
of another kind of
outcome measure we
commonly measure in
clinical trials and this is
health-related quality of life.
0:15
Here, I'm going to
give a brief overview
of how quality of life
(QoL) is defined,
what sorts of features or
symptoms it brings out,
how we measure it, and
quickly how we interpret it.
0:29
As with the two
previous sessions,
one on efficacy
and one on harms,
this is another kind of
major outcome measure
we can obtain from patients
or participants in
a clinical trial.
They're a bit
different to efficacy
and harms which are usually
assessed by a
health professional
using visual observation of
things that go wrong or
biochemical test,
physiological tests, or scans.
For many years, focus was on
improving clinical outcomes to
efficacy and reducing harms
particularly in core
prognosis disorders.
However, in modern times,
many interventions don't have
as many harms as they
had before and there's
also a clear emphasis
on how people or
patients feel when they
take new interventions.
So, as well as efficacy harms
sometimes being
related to each other,
Health-related
quality of life (QoL)
can also reflect some elements
of efficacy and harms but it's
viewed as being a topic
in its own right.
1:32
One of the key definitions of
health-related QoL is
that it's a
self-reported measure.
So, unlike many efficacy or
harms outcomes that
are assessed by
health professional
often with the person
there as well and
using tests or scans,
most QoL measures are
self-reported by
participants themselves.
This may involve a
health professional
alongside them to help understand
some of the questions,
but it's the patients or
participants perceived view
of how they live their lives and
how the intervention
affects their lives.
Health-related QoL measures
for parents and
carers of patients
not just patients themselves.
QoL is the example
of Patient Reported Outcomes
(PROMs) and they reflect
the general health
and experiences and
well-being of people who've
taken new intervention
to be compared with
those who take the control
or standard comparative.
