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0:00
Hello, I'm Allan Hackshaw, and I'm going to give a short session about assessing efficacy in the context of clinical trials.
0:10
In this short session, we're going to cover how efficacy is defined, what makes an efficacy measure 'good', how it's evaluated, and I'll end with a very simple example of evaluating efficacy.
0:25
Efficacy is a measure of clinical or public health benefit. It's usually quite well defined, often very obvious such as death or the development of a disorder such as heart disease, stroke or cancer, and it can be measured in many ways depending on the disorder of interest. It can be used to reflect chronic symptoms and other disorders that are similar that last a long time. Benefit is a very general word that means do we reduce the risk of something bad happening such as a clinically relevant disorder or death, or do we improve or even stabilize symptoms?
1:03
Measures of efficacy often depend on the different disease types and states. Two extreme ones are acute disorders such as advanced cancers, heart attack, strokes where people often die from that disorder or there are chronic disorders such as asthma, psoriasis, depression that people have for most of their lives. Individuals with acute or chronic disorders may want different impacts on them from different interventions. When we measure efficacy it's not just the point of view of the health professional, but also what matters to patients. The expectations of benefit also differ between different types of disorders and different types of people, such as healthy people, are we looking at new interventions to prevent something bad happening later on, or are we looking to treat people who already have the disorder of interest? Their expectations or what they want out of efficacy and interventions may be quite different to each other. There's no simple single rule in terms

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