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Hello. My name is Susan Fairweather-Tait. I'm professor of Human Nutrition in the Norwich Medical School at the University of East Anglia in the UK. I'm going to be talking to you about fluoride.
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Fluoride has no known essential function in human growth and development. It's mainly associating in the body with calcified tissue that's bones and teeth and it's found as calcium fluorapatite. It's been known for more than 100 years that it's useful in the control of dental caries development. Apart from incorporating fluoride into forming enamel of teeth before eruption, dietary fluoride will exert an anti-caries effect on erupted teeth and this happens through contact with enamel during ingestion, excretion into saliva, and uptake into biofilms on teeth. This is the mechanism whereby fluoridated toothpaste works. In bones, the partial substitution of fluoride for hydroxyl groups of apatite alters the mineral structure of the bone and this results in increased density and hardness of the bone but it doesn't affect the mechanical strength. In fact, no associations have been found between serum fluoride concentrations which reflect intake and bone mineral density or osteoporotic fractures. In other words, it may make the bones harder but it doesn't actually stop the fractures occurring.
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The major food sources of fluoride are water and water-based beverages, particularly from high fluoride water and foods reconstituted with fluoridated water or using fluoridated salt. These examples would be soup or infant formulae. The levels can be very high in fish products that contain bones. If you eat the bones which are soft such as in canned salmon and sardines, you'll get fluoride and also tea contains quite a lot of fluoride. Now in a number of countries, water fluoridation is carried out and this is because the water is naturally low in fluoride and it's known to help with dental caries prevention. That's the reason for doing this. The optimal concentration they're aiming for in drinking water is in the range of 0.5-1 milligrams per liter. You can see the maps of the world showing the probability of naturally occurring fluoride in groundwater exceeding the WHO drinking water guideline which is 1.5 milligrams per liter and the green areas showing there's very low probability. As you go up to yellow and orange and red and pink, the probability increases. You can see there are some countries where for example Western US and Mexico, South America, South Africa and South Asia, there are very high probability of fluoride being very high levels in the groundwater. But the map shows quite nicely that it's a very varied distribution across the world and also within countries, which means that water fluoridation has to be carried out at a very local level. In the world probably the highest area of

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