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Printable Handouts
Navigable Slide Index
- Introduction
- Which tubular activity is bigger?
- Where is reabsorption greatest along the nephron?
- Which of these solutes are actively reabsorbed?
- Solute reabsorption: proximal convoluted tubule
- What is the most important solute to be reabsorbed?
- Sodium reabsorption
- Sodium reabsorption in the proximal tubule
- Sodium and glucose reabsorption in the proximal tubule
- Sodium reabsorption in the proximal tubule: other solutes
- Why does glucose appear in the urine of diabetics?
- Glucose titration curve
- Sodium in acid-base balance
- How does the body detect sodium balance?
- Sodium balance: intake = output
- Sodium balance
- Change in blood volume following saline infusion
- Body fluids
- Sodium excretion can be altered by the following
- Effects of aldosterone
- Characteristics of hyperaldosteronism
- Thank you for listening
Topics Covered
- Solute reabsorption
- Active sodium reabsorption
- Secondary active transportation of solutes with sodium
- Glucose titration curve
- Renal regulation of acid-base balance
- Sodium balance
- Water distribution in the body
- Aldosterone mediated sodium reabsorption
Links
Series:
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Therapeutic Areas:
Talk Citation
Briffa, J. (2024, March 31). Renal function: sodium balance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 7, 2024, from https://doi.org/10.69645/XBXW9685.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Other Talks in the Series: Fundamentals of Human Physiology
Transcript
Please wait while the transcript is being prepared...
0:00
Hello and welcome back to
The Fundamentals of
Human Physiology.
My name is Jessica Briffa.
Today, we'll be going
through the third lecture in
the 'Kidney Function' series,
which is on sodium balance.
0:16
Before we delve into this topic,
I have a few
stop-and-think questions
that are designed as a refresher
for the content
already covered and
to get you started
thinking about this topic.
First, let's consider
the following question.
What tubular activity
do you think is bigger?
As you may recall from
the first lecture,
reabsorption and secretion
occurs throughout the nephron.
We also know that 20% of
plasma is filtered
into the nephron.
However, less than 1% of the
volume is excreted as urine.
It may not be too
surprising that
reabsorption is a
bigger tubular process.
0:59
Now that we know
that reabsorption
is the biggest tubular activity,
let's consider the
following question.
Where do you think
tubular reabsorption
is of the greatest
along the nephron?
If you think back to the
structure of the nephron,
you'll appreciate that
the first segment
of the tubule that
the glomerular filtrate
comes into contact
with is the proximal
convoluted tubule.
It is not too surprising
that this is a site where
the majority of solute and
water reabsorption occurs,
which is responsible for
reabsorbing 50-60% of
glomerular ultrafiltrate.
The reabsorption that occurs in
the proximal
convoluted tubules is
primarily driven by the
reabsorption of sodium ions;
a topic which we will expand
upon in this lecture.