• Introduction to Calcium Signaling
• 72 min
  1. Introduction to cellular calcium signaling

  • Dr. Martin Bootman
• 20 min
  2. Monitoring Ca2+ concentration in living cells

  • Dr. Marisa Brini
• 30 min
  3. Cell boundary theorem

  • Prof. Eduardo Ríos
• Calcium Influx
• 19 min
  4. Arachidonic acid and store-independent Ca2+ entry

  • Dr. Luca Munaron
• 34 min
  5. Voltage-dependent calcium channels

  • Prof. Annette Dolphin
• 34 min
  6. Protein networks of voltage-gated Ca2+ channels – proteomic & functional analysis of local Ca2+ signalling

  • Prof. Bernd Fakler
• 37 min
  7. Intracellular Ca2+ signaling: calcium influx

  • Prof. Anant Parekh
• 60 min
  8. Molecular identification of the CRAC channel

  • Prof. Michael Cahalan
• 35 min
  9. TRP channels with diverse permeability profiles: regulation of blood pressure and fertility

  • Prof. Marc Freichel
• Calcium Release
• 53 min
  10. The InsP3 receptor calcium release channel

  • Prof. J. Kevin Foskett
• 31 min
  11. Molecular biology of ryanodine receptors: an overview

  • Dr. Christopher George
  • Prof. F. Anthony Lai
• 57 min
  12. cADPR and NAADP: messengers for calcium signalling

  • Prof. Antony Galione
• 43 min
  13. Ryanodine receptors and cardiac function

  • Prof. David Eisner
• Calcium Efflux and Sequestration
• 45 min
  14. Sodium-calcium exchange

  • Prof. John Reeves
• Organelle Calcium
• 42 min
  15. Regulation and role of mitochondrial Ca2+ homeostasis

  • Prof. Rosario Rizzuto
• 54 min
  16. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis

  • Dr. Paola Pizzo
  • Dr. Alex Costa
• 34 min
  17. Ca2+ dynamics between mitochondria and the endoplasmic reticulum

  • Dr. Wolfgang Graier
• 26 min
  18. Nuclear calcium signaling

  • Dr. Oleg Gerasimenko
  • Dr. Julia Gerasimenko
• Spatiotemporal Calcium Signals
• 54 min
  19. Regulation of intracellular calcium signaling, localized signals and oscillations

  • Prof. Barbara Ehrlich
• 43 min
  20. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells: introduction and basic concepts

  • Dr. David Friel
• 41 min
  21. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells - Ca2+ stores: endoplasmic reticulum, calcium oscillations

  • Dr. David Friel
• 49 min
  22. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells - Ca2+ stores: mitochondria, models of spatially non-uniform Ca2+ signals, applications to analysis of experimental results

  • Dr. David Friel
• Calcium Effectors
• 34 min
  23. Neuronal calcium sensor proteins: calcium sensors and regulators of diverse cellular functions

  • Prof. Bob Burgoyne
• 41 min
  24. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization

  • Prof. Dermot Cooper
• 32 min
  25. Calcium and transcription-coupling

  • Dr. Karen Lounsbury
• 50 min
  26. Cellular calcium (Ca2+) buffers

  • Prof. Dr. Beat Schwaller
• 24 min
  27. Extracellular calcium signaling

  • Dr. Aldebaran M. Hofer
• 50 min
  28. Ca2+, fertilization and egg activation

  • Prof. Karl Swann
• 24 min
  29. Calcium regulation of transcription in plants

  • Prof. Hillel Fromm
• 34 min
  30. Mechanisms regulating STIM expression and function in Ca2+ signaling

  • Dr. Jonathan Soboloff
• 46 min
  31. Dynamic signal encoding in the S. cerevisiae calcium response

  • Dr. Chiraj Dalal
• Calcium and Disease
• 43 min
  32. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease

  • Prof. Laura del Senno
• 28 min
  33. Ca2+ alterations in familial Alzheimer's disease (FAD)

  • Dr. Paola Pizzo
• 38 min
  34. Pancreatitis and calcium signaling

  • Prof. Ole Petersen
• 47 min
  35. Mechanism-based therapies for heart failure and cardiac arrhythmias

  • Prof. Andrew Marks
• 46 min
  36. Genetic defects and calcium

  • Prof. Tullio Pozzan
• Archived Lectures *These may not cover the latest advances in the field
• 31 min
  37. Calcium, calmodulin and calcineurin

  • Prof. Stephen Bolsover
• 34 min
  38. Calcium flickers steer cell migration

  • Prof. Heping Cheng
• 28 min
  39. Automated Ca2+ imaging of chemosensory neurones in C.elegans

  • Dr. Nikos Chronis
• 46 min
  40. Ca2+ and the regulation of small GTPases

  • Prof. Peter Cullen
• 35 min
  41. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo

  • Dr. Michael I. Kotlikoff
• 35 min
  42. Capacitative (store-operated) calcium entry

  • Dr. Jim Putney
• 47 min
  43. The molecular biology of the inositol trisphosphate receptor

  • Dr. Randen Patterson
• 50 min
  44. Coordinated Ca2+ release from intracellular Ca2+ stores

  • Prof. Ole Petersen
• 45 min
  45. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology

  • Prof. Ernesto Carafoli
• 60 min
  46. The calcium saga: a matter of life and death

  • Prof. Pierluigi Nicotera
• 22 min
  47. Ca2+ efflux and Ca2+ signals

  • Dr. Anne Green
• 31 min
  48. Organellar calcium pumps of the golgi and ER: from yeast to human

  • Prof. Rajini Rao
• 58 min
  49. Spatial and temporal aspects of cellular calcium signals: 'elementary' signals and waves

  • Prof. Ian Parker
• 26 min
  50. Modeling Ca2+ signals

  • Dr. David Friel

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Calcium is an ubiquitous messenger
3. Spatial control of calcium
4. Calcium-reporting dyes
5. Basic mechanisms of calcium regulation
6. Why have internal calcium stores and release?
7. Some organelles that serve as calcium stores
8. Ca mobilization by hormones/ neurotransmitters
9. Calcium mobilizing messengers
10. Intracellular signaling by IP3
11. Structures of calcium mobilizing messengers
12. Multiple Ca release mechanisms
13. cADPR activity was discovered in sea urchin eggs
14. Studying Ca release in cell-free systems
15. Ca release in urchin egg homogenates
16. Role of cADPR in calcium signaling
17. Second messenger roles for cADPR
18. cADPR/NAADP synthesis, analogues and drugs
19. Synthesis of cADPR and analogues
20. Caged cADPR photolysis induces Ca waves
21. Caged Ca photolysis evokes local Ca rise
22. Potentiation of CICR by cADPR
23. Ryanodine receptors: function
24. Ryanodine receptors: imaging elementary events
25. Photolysis released cADPR and Ca transients
26. cADPR antagonist abolishes Ca waves
27. cADPR increases the frequency of Ca sparks
28. Mechanism of enhanced Ca release by cADPR
29. Isoprenaline-evoked increases in cADPR levels
30. Pharmacology of cADPR increases
31. Role of cADPR in cardiac E-C coupling
32. Summary of cADPR activity
33. cADPR in Ca signaling
34. What is NAADP
35. Photolysing caged NAADP results in a Ca wave
36. Spatial sensitivity to low [NAADP]
37. Effect of CICR channels inhibition
38. NAADP: spatial/ temporal aspects of Ca signals
39. NAADP stores are separate from the ER
40. Stratification of sea urchin eggs
41. GPN rupture lysosomes
42. Lysotracker
43. GPN ruptures lysosomes and releases Ca
44. NAADP is an initiator: Ca-induced Ca release
45. NAADP releases Ca from lysosomal stores
46. Organelle marker enzymes
47. Receptor distribution
48. Ca uptake into NAADP-sensitive stores
49. NAADP: special channel or special regulation?
50. Inhibition of NAADP-induced Ca release
51. NAADP-induced calcium release
52. NAADP-induced Ca release amplification by RyR
53. Bafilomycin inhibits NAADP-induced Ca release
54. Interactions between NAADP and CICR channels
55. Auto-inactivation of NAADP-induced Ca release
56. Specificity of receptor-mediated NAADP signaling
57. NAADP triggers global Ca signals
58. CCK-evoked calcium spiking blocked by GPN
59. CCK-evoked calcium spiking blocked: bafilomycin
60. Selectivity in GPN blockage
61. Radio-receptor assay for NAADP levels
62. CCK-induced changes in NAADP / cADPR levels
63. NAADP: trigger hypothesis
64. Receptor specificity in pancreatic acinar cells
65. ARC can synthesize cADPR and NAADP
66. NAADP changes in CD38-/- mouse
67. NAADPR is easily solubilized as a native protein
68. Affinity purification of the NAADP receptor
69. NAADP binding proteins
70. Summary

Topics Covered

• Calcium signaling mechanisms
• Calcium stores and calcium mobilization
• Intracellular calcium release channels
• cADPR as an intracellular messenger
• Ryanodine receptors
• Cardiac excitation
• Coupling
• NAADP
• Acidic calcium store
• Smooth muscle cell calcium signaling
• Calcium spiking
• NAADP receptors

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Antony Galione has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.