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Navigable Slide Index

1. Introduction
2. Haplotype tagging SNPs
3. The htSNP approach
4. Tag SNPs in LD blocks (1)
5. Tag SNPs in LD blocks (2)
6. Tag SNPs in LD blocks (3)
7. A simple model
8. Indirect association
9. Scoring htSNP genotypes
10. R2: our recent experience
11. Some lessons
12. Case-control studies
13. Power
14. Complexity vs. accuracy
15. An experimental study
16. Power in CTLA4
17. Power in RANK
18. Power in TH 5' region 2
19. Power in TH-INS-IGF2
20. Tests based on locus scoring
21. A "multilocus TDT"
22. From htSNPs to causal variants
23. Selecting htSNPs N=96 (1)
24. Selecting htSNPs N=96 (2)
25. Selecting htSNPs N=48 (1)
26. Selecting htSNPs N=48 (2)
27. Selecting htSNPs N=32 (1)
28. Selecting htSNPs N=32 (2)
29. Selecting htSNPs N=16 (1)
30. Selecting htSNPs N=16 (2)
31. Quantitative traits
32. One df for dominance
33. Acknowledgements and reference

Topics Covered

• The htSNP approach
• R-square criterion for assessment
• Power
• Complexity vs. accuracy
• Case studies: 4 gene regions
• From htSNPs to causal variants
• Quantitative traits
• 1 df for dominance

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Clayton, D. (2004, September 1). Searching for genetic association using (haplotype) tagging SNPs [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 30, 2024, from https://doi.org/10.69645/ODPW5613.
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Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. David Clayton has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.