Expanding roles of RNA-binding proteins in neurodegenerative diseases

Published on November 30, 2017   47 min

Other Talks in the Series: ALS and Other Motor Neuron Disorders

Other Talks in the Series: Protein Folding, Aggregation and Design

The title of my talk is Expanding Roles of RNA-Binding Proteins in Neurodegenerative Diseases. My name is Aaron Gitler; I'm a professor in the Department of Genetics at Stanford University School of Medicine.
My laboratory is interested in the mechanisms of human neurodegenerative diseases. These diseases include Alzheimer's disease, Parkinson's disease, Huntington's and ALS. As our population continues to age, these diseases are increasing in prevalence. They have several different clinical presentations, ranging from memory loss in Alzheimer's disease to movement impairments in Parkinson's disease. Despite these differences in clinical presentation, there's a common theme that unites all neurodegenerative diseases - and this is protein misfolding. Proteins accumulate and aggregate in the brains of patients affected with these diseases, and my laboratory is trying to understand the cellular pathways affected, when misfolded human disease proteins aggregate.

Expanding roles of RNA-binding proteins in neurodegenerative diseases

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