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- View the Talks
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38 min
1. Adaptive clinical trials: overview 1- Prof. Yu Shyr
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27 min
2. Adaptive clinical trials: overview 2- Prof. Yu Shyr
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42 min
3. Bayesian adaptive designs for clinical trials- Prof. Benjamin Saville
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32 min
4. Adaptive clinical trial design: randomization- Prof. Hao Liu
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31 min
5. Adaptive designs for phase I trials 1- Prof. Anastasia Ivanova
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22 min
6. Adaptive designs for phase I trials 2- Prof. Anastasia Ivanova
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44 min
7. Case studies of adaptive early phase trials- Prof. Daniel Normolle
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34 min
8. Phase II clinical trials - traditional approaches- Prof. Fei Ye
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23 min
9. Phase II clinical trials - Bayesian methods- Prof. Fei Ye
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40 min
10. Seamless phase II/III trials- Prof. Elizabeth Garrett-Mayer
- Mr. Nathaniel O’Connell
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35 min
11. Frequentist approaches: sample size in adaptive clinical designs- Prof. Tatsuki Koyama
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26 min
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20 min
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30 min
14. Ethical issues in adaptive clinical trials- Dr. Spencer Phillips Hey
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47 min
15. Implementation of adaptive methods in early phase clinical trials- Prof. Gina Petroni
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29 min
16. Design early phase drug combination trials: methods- Prof. Ying Yuan
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33 min
17. Design early phase drug combination trials: software- Prof. Ying Yuan
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51 min
18. Adaptation in likelihood trials- Prof. Jeffrey Blume
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43 min
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Definition of an adaptive clinical trial
- FDA: guidance for industrial adaptive design
- Type of the adaptive trials
- Three major types of trials
- Three types of clinical endpoints
- Two types of adaptive design
- Biomarker-adaptive clinical trials design
- Recently FDA approved drugs (1)
- Recently FDA approved drugs (2)
- Recently FDA approved drugs (3)
- Prognostic marker
- Predictive marker
- Enrichment designs
- Biomarker-stratified design (1)
- Biomarker-stratified design (2)
- Randomized hybrid design
- Umbrella and basket trials
- Examples of phase I, II, and III trials
- Phase I: CRM (1)
- Phase I: CRM (2)
- Schematic of CRM phase I trial
- Adaptive randomization phase II designs (1)
- Adaptive randomization phase II designs (2)
- Adaptive randomization phase II designs (3)
- Adaptive randomization phase II designs: summary
- Umbrella trial example
- Future directions
- Thanks for listening
Topics Covered
- Definition of an adaptive clinical trial
- Three major types of trials
- Three types of clinical endpoints
- Biomarker-adaptive clinical trials design
- Recently FDA approved drugs
- Prognostic marker
- Predictive marker
- Enrichment designs
- Biomarker-stratified design
- Randomized hybrid design
- Umbrella and basket trials
- Examples of phase I, II, and III trials
Talk Citation
Shyr, Y. (2017, August 31). Adaptive clinical trials: conclusion and future directions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/PYFU2183.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Yu Shyr has no commercial/financial relationships to disclose
Adaptive clinical trials: conclusion and future directions
Published on August 31, 2017
43 min
A selection of talks on Pharmaceutical Sciences
Transcript
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