We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Structure of talk
- First description of aphasia in context of MND
- Cognitive & behavioural symptoms in ALS (1)
- Cognitive & behavioural symptoms in ALS (2)
- Cognitive & behavioural changes in ALS
- Dementia associated with ALS: Clinical features
- Behavioural changes in ALS
- Cognitive changes in ALS
- Cognition in ALS: The state of the art 2016
- Deficits in language
- Language comprehension in MND/Dementia
- Noun/verb naming & comprehension in MND
- Kissing & dancing test
- FTD/MND compared to other syndromes
- Why has overwhelming evidence been neglected?
- Language, cognition & behaviour in MND
- The progression of ALS
- FTD & MND: One, two or three diseases
- Movement, cognition & behaviour
- Shortcomings in addressing motor symptoms
- Assessing cognitive functions with motor symptoms
- Edinburgh Cognitive Assessment (ECAS)
- ECAS: Language
- ECAS: Verbal fluency
- ECAS: Executive functions
- ECAS: Social cognition
- ECAS: Memory
- ECAS: Visuospatial functions (without drawing)
- ECAS subdomains
- Integrating cognition & behaviour with biology
Topics Covered
- Cognition & behavioural deficits in ALS
- Dementia associated with ALS
- Language, cognition & behaviour in MND
- Onset vs. progression of ALS
- Why cognition is affected in ALS
- Assessment of cognitive symptoms in ALS (ECAS)
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Bak, T. (2022, May 4). Cognition in ALS and the overlap with frontotemporal dementia (FTD) [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/EWJP5691.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Thomas Bak has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: ALS and Other Motor Neuron Disorders
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Dr. Thomas Bak
and I work
at the University of Edinburgh.
I would like to speak about
cognition in ALS
and in particular
about the overlap
with frontotemporal dementia.
Now you might start asking
what is cognition in ALS,
isn't it referred to
as motor neuron disease
which per definition
should be motor.
I hope that
by the end of this lecture,
I would have convinced you
not only that
cognition is
a very important part
for the clinical
in vitro of ALS,
but that it is an absolutely
integral part
for our understanding
of the disease.
0:37
So to start with
the structure of the talk,
I will first speak about
the history of our discovery
of cognitive symptoms in ALS,
addressing the question
whether this is really
a recent discovery
or something which in fact
can go back much more in time.
I will then move to discuss
the nature
of cognitive deficits,
in particular the
frontal-executive dysfunction,
social cognition behavior,
and language.
And then I would come to what
I think is a central question,
why is cognition affected
in ALS, and finally,
after hopefully convincing you
that it's an important
part of the disease,
I want to speak a little bit
about assessment
of cognitive symptoms,
how can we assess them,
how can we really judge
whether they're present or not.
1:23
So you might be surprised
that the first slide
I start with here is from 1893,
quite long time ago
and incidentally from Japan.
This was until recently
and arguably little known
piece of work
published in Journal
of the Medical Society
of Okayama,
which would not be famous
even in Japan,
but I think
this is very interesting.
It happens to be the first
description of aphasia,
namely language disorder
associated with
brain disease in Japan.
But what makes it really
interesting is that
this first description
of aphasia
was in context
of motor neuron disease.
So already in 19th century,
physicians have noticed that
at least some of the patients
with ALS
might have something wrong
with their cognitive functions.
In this case interestingly,
there's a description
of a disorder of speaking
but also of writing and reading,
affecting one part
of Japanese writing,
kana more than kanji,
I will come to it much later
where I just hope
it will become relevant.