Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Preface
3. Linkage vs. association
4. Genealogy of case chromosomes (1)
5. Genealogy of case chromosomes (2)
6. Descent of founder haplotype
7. Reality is more complex (1)
8. Reality is more complex (2)
9. Reality is more complex (3)
10. Disease-marker association
11. Non-genealogy-based association methods
12. Star genealogies (1)
13. Star genealogies (2)
14. Star genealogies (3)
15. Adjusting for shared ancestry
16. Coalescent model
17. Pros and cons of the coalescent
18. The shattered coalescent (1)
19. The shattered coalescent (2)
20. Bayesian computation
21. Bayes' theorem
22. Simplifying the likelihood
23. DMLE (Rannala & Reeve, 2001)
24. COLDMAP (Morris et al., 2002)
25. Genetic heterogeneity
26. Example: cystic fibrosis
27. Single-marker odds ratios
28. COLDMAP analyses
29. CF location
30. CF cladogram
31. Unphased genotype data
32. Perspectives
33. References

Topics Covered

• Linkage vs. association
• The need for fine mapping
• The genealogy underlying a sample of case chromosomes
• Disease-marker association
• Star genealogies and variance adjustment
• Coalescent-based approaches
• Software: DMLE+ and COLDMAP
• Example: CF dataset

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. David Balding has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Dr. Andrew Morris has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.