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1. Introduction
2. Changes in habitat and life style
3. Neutral and selected mutations trajectories
4. Selection around polymorphic advantageous allele
5. Selection around a fixed advantageous allele
6. Distinguishing between demography and selection
7. Two types of approaches
8. Duffy blood group locus (FY): a case study
9. FY*0 occurs at near-fixation frequency in Africa
10. FY*0 allele: outlier in the human Fst distribution
11. The signature of a selective sweep (1)
12. The signature of a selective sweep (2)
13. Resequencing survey of the FY region in Africa
14. The FY*0 allele is found on two major haplotypes
15. Sweeps on standing neutral variation
16. Highly differentiated SNPs in the HapMap data
17. Detecting signals of local adaptations
18. Lactase gene is associated with selection signal
19. Distribution of lactase persistence
20. Selection on lactase persistence in Africa
21. Human skin pigmentation
22. Mechanisms of adaptations in pigmentation
23. Genes responsible for Mendelian forms of albinism
24. Local adaptations at the CYP3A genes
25. Re-sequencing survey of the CYP3A gene cluster
26. CYP3A5*1/*3 in the HapMap data
27. CYP3A variation and sodium retention
28. Human genome diversity panel
29. Salt sensitivity variants frequency
30. Human migrations out of Africa
31. Variants affect Na homeostasis vs. random ones
32. Hypertension variants are correlated with latitude
33. Summary

Topics Covered

• Changes in habit and life style during human evolution
• Evolutionary dynamics of neutral and advantageous mutations
• Signature of natural selection on patterns of variation linked to an advantageous variant
• Distinguishing between demography and natural selection
• Duffy blood group locus
• Lactase persistence
• Skin pigmentation
• Salt sensitivity variants and hypertension

Links

Series:

• Human Population Genetics I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Di Rienzo, A. (2007, October 1). The signature of local adaptations in human polymorphism data [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 16, 2025, from https://doi.org/10.69645/XWRY9314.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Anna Di Rienzo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.