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1. Introduction
2. C.elegans is simple, yet sophisticated (1)
3. C.elegans is simple, yet sophisticated (2)
4. Nobel prize 02' was awarded to 3 worm workers (1)
5. C.elegans hermaphrodite cell lineage
6. Apoptosis in C.elegans (1)
7. C.elegans embryonic development
8. Time course of P11.aap death (Nomarski optics)
9. Nobel prize 02' was awarded to 3 worm workers (2)
10. C.elegans genetic programmed cell death
11. C.elegans ced-3, ced-4 and ced-9 genes (1)
12. Programmed cell death in the pharynx
13. C.elegans ced-3, ced-4 and ced-9 genes ( 2)
14. Activation of cell death machinery in C.elegans (1)
15. Activation of cell death: C.elegans vs. mammals
16. Mitochondria fragment during apoptosis
17. Activation of cell death machinery in C.elegans (2)
18. How does apoptosome activation regulated?
19. Cell death activation via EGL-1 regulation
20. Mutations in ces genes
21. ces (cell death specification) genes
22. ces genes mode of action model
23. ces-1 and ces-2 encode transcription factors
24. Conserved transcriptional regulation of apoptosis?
25. Summary: apoptosis regulation in C.elegans
26. Apoptosis in C.elegans ( 2)
27. The adult C.elegans hermaphrodite germ cell line
28. DNA damage induces germ cell apoptosis
29. Radiation-induced germ cell apoptosis
30. Effect of ced-9 (gf) or egl-1 (lf) on apopatosis (1)
31. Transcriptional control of EGL-1 expression
32. egl-1 mRNA levels increase following irradiation
33. C.elegans p53 homolog: CEP-1
34. A model for C.elegans DNA damage response (1)
35. C.elegans checkpoint genes (1)
36. A model for C.elegans DNA damage response (2)
37. Simplified yeast DNA damage checkpoint pathway
38. HUS1:GFP relocalizes to foci after DNA damage
39. Hus1/rad-9 pathway is conserved through evolution
40. A model for C.elegans DNA damage response (3)
41. C.elegans checkpoint genes (2)
42. C.elegans rad-5/clk-2 genes
43. Summary: DNA damage response pathway
44. The evolution of DNA damage response
45. Effect of ced-9 (gf) or egl-1 (lf) on apopatosis (2)
46. Effect of gla-3 (lf) on germ cell apoptosis
47. GLA-3 is a candidate RNA-binding-protein
48. GLA-3 interacts with MPK-1
49. GLA-3 binds to effector docking site of MPK-1
50. Ras-MAPK pathway is required to exit mitosis
51. Ras-MAPK as a transient developmental stage
52. EGF signaling pathway in C.elegans
53. Genetic pathway for programmed cell death (1)
54. Mutations in engulfment genes (1)
55. Mutations in engulfment genes (2)
56. Recognition and removal of apoptotic cells
57. Genetic pathway for programmed cell death (2)

Topics Covered

• Programmed cell death in C. elegans during development and adulthood
• Differentiation
• The genetic pathway for programmed cell death
• ced-3, ced-4 and ced-9
• Activation of the cell death machinery during C. elegans development and in C. elegans vs. mammals
• How does C. elegans regulate activation of the apoptosome?
• Cell death specification (ces) genes
• NSM sister cell death
• Transcription factors
• A model for C. elegans DNA damage response
• gla-3
• A molecular model for the recognition and removal of apoptotic cells in C. elegans

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Michael Hengartner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.