• Archived Lectures *These may not cover the latest advances in the field
• 38 min
  1. Segregation analysis

  • Prof. Chris Cannings
  • Dr. Dawn Teare
• 35 min
  2. Choosing the right study design in genetic epidemiology

  • Prof. Duncan Thomas
• 27 min
  3. Genome-wide scans

  • Prof. Michael Province
• 40 min
  4. The study of candidate genes in drug trials - sample size considerations

  • Prof. Robert Elston
• 48 min
  5. Graphical modelling of linkage disequilibrium

  • Prof. Alun Thomas
• 50 min
  6. Bayesian approaches for modelling complex metabolic pathways

  • Prof. Duncan Thomas
• 53 min
  7. Current methods for the analysis of genetic case-control data: a review

  • Prof. Duncan Thomas
• 44 min
  8. Detecting and correcting for population structure in genetic case-control studies

  • Dr. Jonathan Pritchard
• 57 min
  9. Statistical characterization of genetic association

  • Prof. Bruce Weir
• 34 min
  10. Haplotype-based mapping and pharmacogenetics

  • Prof. David Goldstein
• 50 min
  11. Genetic linkage analysis

  • Prof. Christopher Amos
• 30 min
  12. Use of DNA pooling in large-scale association studies

  • Prof. Pak Sham
• 29 min
  13. Searching for genetic association using (haplotype) tagging SNPs

  • Prof. David Clayton
• 27 min
  14. Heterogeneity: problems and solutions

  • Prof. Michael Province
• 37 min
  15. Introduction to population genetics 1: single locus

  • Prof. David Balding
  • Dr. Andrew Morris
• 57 min
  16. Haplotype phase inference

  • Prof. Peter Donnelly
• 38 min
  17. Optimal use of linkage disequilibrium, haplotypes, and integrated maps for positional cloning

  • Prof. Newton Morton
  • Dr. Andrew Collins
• 58 min
  18. Introductory genetics for statisticians

  • Prof. Robert Elston
• 30 min
  19. Nature, nurture, neither?

  • Prof. Steve Jones
• 35 min
  20. Introduction to population genetics 2: linkage disequilibrium

  • Prof. David Balding
  • Dr. Andrew Morris
• 34 min
  21. Fine-scale mapping

  • Prof. David Balding
  • Dr. Andrew Morris

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Mendelian vs. complex diseases (1)
3. Mendelian vs. complex diseases (2)
4. Approaches to gene discovery (1)
5. Approaches to gene discovery (2)
6. Linkage analysis
7. Approaches to linkage analysis
8. Affected sib pair method
9. LOD score method
10. Mendelian diseases
11. Complex diseases
12. Genetic association
13. Designs for studying associations
14. Association studies using unrelated individuals
15. Control for population stratification
16. Case-parent-triad design (1)
17. Case-parent-triad design (2)
18. Discordant sibship design (1)
19. Discordant sibship design (2)
20. Extensions of family-based case-control designs
21. Discordant sibships: example
22. Are larger sibships really cost-effective?
23. Use of younger sibs as controls
24. Kin cohort design
25. Kin cohort estimates of breast cancer penetrance
26. High risk family designs
27. Complications
28. Genotype decomposition method
29. Whittemore and Halpern method
30. Subtleties
31. Interaction effects
32. Multistage sampling designs
33. Use of unrelated controls
34. Case-control-family design
35. Combining analysis using different designs
36. Power for association studies
37. Sample size software
38. Quanto program (1)
39. Quanto program (2)
40. Quanto program (3)
41. Quanto program (4)
42. Quanto program (5)
43. Quanto program (6)
44. Quanto program (7)
45. Quanto program (8)
46. Quanto program (9)
47. A suggested approach (1)
48. A suggested approach (2)

Topics Covered

• Mendelian vs. complex diseases
• Approaches to gene discovery
• Overview of linkage and association analysis
• Association study designs
• Control for population stratification
• Use of younger siblings as controls
• Complications and subtleties
• Combining analyses using different designs
• Power for association studies

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. Duncan Thomas has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.