• View the Talks
• 50 min
  1. Where the thoughts dwell: history of neuroscience and introduction into neuroglia

  • Prof. Alexei Verkhratsky
• 35 min
  2. Astrocytes: definition, appearance and general physiology 1

  • Prof. Alexei Verkhratsky
• 30 min
  3. Astrocytes: definition, appearance and general physiology 2

  • Prof. Alexei Verkhratsky
• 39 min
  4. Glial calcium signalling

  • Prof. Alexei Verkhratsky
• 33 min
  5. Astroglial calcium signalling: what it could tell us

  • Prof. Dmitri Rusakov
• 42 min
  6. Neuronal-glial chemical transmission mediated by glutamate and ATP

  • Prof. Alexei Verkhratsky
• 27 min
  7. Energy and amino acid neurotransmitter metabolism in astrocytes

  • Prof. Helle Waagepetersen
• 49 min
  8. Mechanisms of glutamate release from astrocytes

  • Prof. Vladimir Parpura
• 37 min
  9. Cannabinoid type 1 receptors in astrocytes

  • Prof. Giovanni Marsicano
• 34 min
  10. Neuronal-glial anatomical plasticity in the hypothalamus

  • Dr. Stéphane H.R. Oliet
• 25 min
  11. General physiology of oligodendrocytes

  • Prof. Arthur M. Butt
• 35 min
  12. Neuropathology of microglia and oligodendrocytes

  • Prof. Arthur M. Butt
• 38 min
  13. Oligodendroglia/MCT1 are an unexpected contributor to CNS toxicity/neurodegeneration

  • Prof. Jeffrey D. Rothstein
• 41 min
  14. Physiology and pathophysiology of microglia

  • Prof. Dr. Uwe-Karsten Hanisch
• 39 min
  15. Properties of regulated exocytosis in astrocytes

  • Prof. Robert Zorec
• 49 min
  16. Exocytosis and gliocrine astroglia

  • Prof. Robert Zorec
• 37 min
  17. Noradrenergic hypothesis of neurodegeneration and astroglia

  • Prof. Robert Zorec
• 45 min
  18. Principles of astrogliopathology: from reactivity to atrophy and degeneration

  • Prof. Alexei Verkhratsky
• 23 min
  19. Regulation of synaptic plasticity by astroglia

  • Prof. Dmitri Rusakov
• 48 min
  20. Enteric glia: the glue of the enteric nervous system

  • Dr. Keith A. Sharkey
• 38 min
  21. Purinergic neuron-to-glia signaling in the enteric nervous system

  • Dr. Brian D. Gulbransen
• 43 min
  22. Astrocytes and Alexander disease: the first - but not last - primary astrocyte disease

  • Prof. Albee Messing
• 45 min
  23. Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons

  • Prof. Vladimir Parpura
• 43 min
  24. The impact of astrocyte mitochondrial ATP production on neuroprotection after stroke

  • Prof. James Lechleiter
• 33 min
  25. Hepatic encephalopathy in cirrhosis: a disorder of glial-neuronal signalling

  • Prof. Roger F. Butterworth
• 33 min
  26. Hepatic encephalopathy in acute liver failure: a primary neurogliopathy

  • Prof. Roger F. Butterworth
• 37 min
  27. Bi-directional communication at the neurovascular unit: implications for neuronal function

  • Prof. Jessica A. Filosa
• 51 min
  28. Astrocyte reactivity

  • Prof. Michael Sofroniew
• 36 min
  29. Roles of microglia in the healthy brain

  • Dr. Marie-Ève Tremblay
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  30. Astroglia in neuropathology

  • Prof. Alexei Verkhratsky
• 44 min
  31. Cell biology and physiology of astroglia

  • Prof. Alexei Verkhratsky
• 29 min
  32. General physiology of oligodendrocytes and Schwann cells

  • Prof. Arthur M. Butt

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Schematic diagram of an ischemic stroke
3. Astrocyte neuroprotection (1)
4. P2Y1R stimulation reduces RB infarcts (1)
5. P2Y1R stimulation reduces RB infarcts (2)
6. In vivo optical imaging of mouse parietal cortex
7. Cerebral ischemic stroke in living mouse
8. BBB disruption induced by RB photothrombosis
9. Pre photothrombosis (1)
10. 24 hours post photothrombosis
11. 48 hours post photothrombosis
12. Necrotic core is not anoxic
13. ATP production in astrocytes
14. Ischemic ATP production in astrocytes
15. ATP production in neurons
16. Pre photothrombosis (2)
17. 24 hours post photothrombosis (2MeSADP) (1)
18. 48 hours post photothrombosis (2MeSADP) (2)
19. Pre photothrombosis (3)
20. 24 hrs after stroke (2MeSADP added)
21. 48 hrs after stroke (24 hrs after 2MeSADP added)
22. Astrocyte neuroprotection (2)
23. Fluoroacetate blocks P2Y1R protection
24. MtEcoRI affects the mitochondria potential delta
25. P2Y1R-enhanced neuroprotection
26. Gradient cell swelling towards thrombosis
27. Swelling 3 hours post photothrombosis
28. Cell swelling in more details
29. Cell swelling with 2MeSADP
30. Ischemia induces astrocyte death
31. Astrocyte swelling is reversible
32. Astrocyte neuroprotection (3)
33. P2Y1R decreases brain swelling following TBI
34. P2Y1R decreases cell edema in hippocampus
35. Astrocyte neuroprotection (4)
36. Acknowledgements

Topics Covered

• Schematic diagram of an ischemic stroke at cellular level
• P2Y1-R stimulation
• Photothrombosis
• Pathways involved in ATP production in astrocytes
• Working model of astrocyte neuroprotection
• Ischemia-induced astrocyte cell swelling

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on February 17, 2013

Financial Disclosures

• Prof. James Lechleiter has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.