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- The Basics of Glycan Structure, Biosynthesis, and Function
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28 min
1. Use of heparosan polysaccharide to enhance drug delivery- Prof. Paul L. DeAngelis
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31 min
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49 min
3. O-GlcNAc, an essential regulator of numerous cellular pathways- Dr. Natasha Zachara
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58 min
4. Plant cell wall: structure and biosynthesis- Prof. Debra Mohnen
- Dr. Melani A. Atmodjo
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51 min
5. GPI-anchored glycoproteins- Prof. Michael Ferguson
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52 min
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51 min
7. Structure of cell walls in yeast and other fungi- Dr. Peter Lipke
- Glycan Regulation and Function in Development and Physiology
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49 min
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23 min
9. Glycan regulation of receptor functions- Prof. Naoyuki Taniguchi
- Glycan Involvement in Disease and Disorders
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31 min
10. Congenital disorders of N-glycosylation- Prof. Harry Schachter
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44 min
11. Glycosylation changes during oncogenesis- Prof. Michael Pierce
- Innovative Technologies for Glycoscience and Glycomics
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70 min
12. Protein-glycan interactions- Prof. James Prestegard
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41 min
13. Glycobiology: an untapped source of novel drugs- Dr. John Magnani
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59 min
14. Development of glyco-biomarkers using glycoproteomics technologies- Dr. Hisashi Narimatsu
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40 min
15. GlycoBioInformatics- Dr. René Ranzinger
- Archived Lectures *These may not cover the latest advances in the field
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46 min
16. Glycosyltransferases: structures and mechanisms- Prof. Monica Palcic
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50 min
17. Roles of glycans in yeast cell walls- Dr. Peter Lipke
Printable Handouts
Navigable Slide Index
- Introduction
- Complex carbohydrates
- Glycocalyx: the cell surface carbohydrate layer
- Cell surface carbohydrate interactions
- Biosynthesis of oligosaccharides
- Many tumor markers are Carbohydrates
- Pathogens infecting by carbohydrate recognition
- Lectins: native carbohydrate-binding proteins
- The selectins are therapeutic targets
- Enhancing carbohydrate-lectin interaction
- Bioactive conformation of glycomimetic 69669a
- Preorganization of the bioactive conformation
- Enhancing binding affinity for E-selectin
- E & P-selectins binding to native ligand PSGL-1
- Glycosylation and sulfation of PSGL-1
- Sulfated drug-like fragment-based library
- GMI-1070 is a pan selectin antagonist
- GMI-1070: pre-clinical models
- Effect of GMI-1070 animal models
- Sickle cell Vaso-Occlusive Crisis (VOC)
- Testing the effects of GMI-1070 on VOC
- GMI-1070 for vaso-occlusive crisis
- Effects of GMI-1070 in sickle cell mice
- GMI-1070 extends survival in sickle cell mice
- GMI-1070- synthesized through convergent steps
- Scale-up chemistry and process development
- Organizations involved in GMI-1070 synthesis
- GMI-1070: phase I clinical trial
- Pharmacokinetics of a single dose of GMI-1070
- Phase 1 healthy volunteers - safety summary
- Clinical trials testing effects of GMI-1070
- GMI-1070: summary
- Validation of the potential of glycomimetic drugs
- Summary
- Scientific contributors
Topics Covered
- Glycobiology as an untapped source of innovative drugs
- Rationally designed selectin antagonists based on functional carbohydrates
- Application to inflammation in sickle cell disease crisis
- Drug-like properties now in Phase II clinical trials
- Recognition and validation of glycomimetic drugs by the pharmaceutical industry
Talk Citation
Magnani, J. (2012, November 27). Glycobiology: an untapped source of novel drugs [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 9, 2025, from https://doi.org/10.69645/TTKR2837.Export Citation (RIS)
Publication History
- Published on November 27, 2012
Financial Disclosures
- Dr. John Magnani has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Glycobiology: an untapped source of novel drugs
Published on November 27, 2012
41 min
