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Printable Handouts
Navigable Slide Index
- Introduction
- Regenerative medicine - definition
- In vitro 3d constructs
- TERM targets
- Research stages - cells
- Cell sources
- Somatic stem cells
- Embryonic stem cells
- TERM stem cell sources
- Challenge 1 - how to differentiate stem cells
- Medium supplementation
- Differentiation of adult stem cells
- Challenge 2 - key components of medium
- Medium composition for pneumocyte differentiation
- Increased endoderm differentiation
- Challenge 3 - other methods
- Cell extracts
- Normal cell behaviour
- Challenge 4 - microenvironment
- Microenvironment references
- Microenvironment and differentiation
- Challenge 5 - genetic modification
- Gene modulation and differentiation
- Research stages - materials
- Materials for regenerative medicine
- Materials - recent results
- Research stages - scale up
- Challenge 6 - how to produce enough cells
- Bioreactors
- Bioprocess engineering
- Research stages - per-clinical tests
- Challenge 7 - does it work in vivo
- Animal models - for and against
- Cardiac experiments
- Challenge 8 - applicable to humans
- Clinical trials
- Cardiac clinical trials
- Immunocompatibility
- Nucler transfer and human cloning
- Novalung
- Novalung - mechanism of action
- Conclusions
Topics Covered
- Regenerative medicine aims to repair, regenerate or replace damaged tissues and organs
- Selection of appropriate cell sources
- Plasticity
- Differentiation of stem cells towards target phenotypes
- Medium supplementation
- Exposure to cell extracts
- Direct or indirect co-culture with other cells/tissues
- Genetic modification
- Scaffolds
- Bioprocessing systems
- Pre-clinical testing of novel stem cell-based therapies in animal models of disease
- Clinical trials
- Treatment of ischaemic heart failure with autologous bone marrow stem cells
Talk Citation
Polak, J. and Bishop, A. (2007, October 1). Stem cells and regenerative medicine [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 14, 2024, from https://doi.org/10.69645/KTMZ1026.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Dame Julia Polak has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Dr. Anne Bishop has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.