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• 42 min
  1. Historic introduction to innate immunity

  • Prof. Heiko Herwald
  • Prof. Arne Egesten
• 52 min
  2. Evolution of innate immunity

  • Prof. Jim Kaufman
• 25 min
  3. The phagocytic synapse in distinguishing particulate and soluble stimuli

  • Prof. David Underhill
• 23 min
  4. How bacterial pathogens avoid phagocyte killing

  • Dr. Thomas Areschoug
• 43 min
  5. Origin of myeloid cells

  • Prof. Frederick A. Geissmann
• 67 min
  6. Dendritic cells

  • Prof. Muriel Moser
• 38 min
  7. Eosinophil biology and disorders associated with eosinophilia

  • Dr. Thomas B. Nutman
• 60 min
  8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity

  • Prof. Steven A. Porcelli
• 50 min
  9. Innate-like B cells

  • Prof. John F. Kearney
• 58 min
  10. Cytoplasmic innate immune sensors

  • Prof. Seth Masters
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 28 min
  12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome

  • Prof. Robert Wilkinson
  • Prof. Graeme Meintjes
• 37 min
  13. Antimicrobial peptides in the innate immune system of the lung

  • Prof. Dr. Pieter S. Hiemstra
• 49 min
  14. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 45 min
  15. Heat shock proteins and their role in the immune regulation of inflammation

  • Prof. Willem Van Eden
• 42 min
  16. Tissue damage control confers host tolerance to infection

  • Dr. Miguel P. Soares
• 22 min
  17. Autophagy as a barrier to infection

  • Prof. Michele Swanson
• 42 min
  18. Innate immunity in the intestine in health and disease

  • Prof. Kevin Maloy
• 51 min
  19. Dendritic cells and the eye: their role in the ocular immune response

  • Prof. John V. Forrester
• 26 min
  20. Mononuclear phagocytes and HIV infection

  • Dr. Guido Poli
• 41 min
  21. Th17 cells and innate immunity

  • Prof. Mihai Netea
• 37 min
  22. Epigenetic regulation of innate immunity

  • Dr. Osamu Takeuchi
• 66 min
  23. Intracellular DNA sensing pathways

  • Prof. Veit Hornung
• 52 min
  24. Physiology of innate immunity

  • Prof. Keith W. Kelley
• 49 min
  25. Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage

  • Prof. Catharina Svanborg
• 32 min
  26. Regulation of type 2 immunity by basophils

  • Prof. David Voehringer
• Archived Lectures *These may not cover the latest advances in the field
• 53 min
  27. TLRs, NLRs, DAMPs and PAMPs

  • Prof. Luke O'Neill

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Outline
3. Autophagosomes have a distinct structure
4. Terminology
5. Membrane traffic
6. Yeast geneticists catalyze research
7. Conservation of autophagy components
8. Autophagy is inhibited by mTOR
9. Atg proteins govern autophagy
10. Reagents for autophagy research
11. Monitoring autophagosome formation
12. Monitoring autophagosome decay
13. Pathogens that encounter autophagy
14. Outcomes of microbe encounters
15. Basis for autophagosome accumulation
16. Ultrastructure of Legionella vacuole
17. Legionella route in permissive cells
18. GTPases promote vacuole biogenesis
19. Model: Legionella slows autophagy
20. NLR Naip5 implicated in autophagy
21. Naip5 facts
22. Model: inflammasomes induce autophagy
23. Crohn's disease links NLR, autophagy
24. Nod1 and 2 recruit Atg16L1 protein
25. Shigella evasion of autophagy
26. Listeria evasion of autophagy
27. Autophagy stimulates MHCII pathway
28. Autophagy stimulates MHCI pathway
29. Autophagy in infection and immunity
30. Acknowledgements

Topics Covered

• Autophagosome biogenesis
• Autophagy a regulated intersection of the secretory and endosomal pathways
• Genetic analysis in yeast has accelerated autophagy research
• Autophagy is inhibited by mTOR
• Autophagosome biogenesis is coordinated by a cascade of Atg proteins
• Autophagosomes mature rapidly in C57Bl/6 macrophages
• A wide variety of pathogens encounter the autophagy pathway
• Autophagy in infection and immunity
• Illustrations: Legionella pneumophila
• Shigella flexnerii
• Crohns' disease
• Mycobacterium tuberculosis
• Naip5 NOD-like receptor cytosolic surveillance protein
• Inflammasome components coordinate autophagy and pyroptosis as barriers to infection
• Autophagy enhances MHCI and MHCII antigen presentation

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Prof. Michele Swanson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.