Topics Covered
- Protein homeostasis in mitochondria
- Mitochondria play an important role in ageing and disease
- Quality control of mitochondria is controlled at three different levels
- Protein quality control (PQC) in mitochondria is maintained by mitochondrial chaperones and AAA+ proteases
- Following proteotoxic stress a specific mitochondrial unfolded protein response (mtUPR) is activated
- The AAA+ protease CLPXP is proposed to play a key role in mtUPR signaling
- A novel mtCLPX interacting protein that modulates the activity of mtCLPXP both in vitro and in vivo has been identified
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Talk Citation
Dougan, D.A. (2012, February 2). Protein homeostasis in mitochondria: AAA+ chaperones & proteases [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 3, 2023, from
https://hstalks.com/bs/2229/.
Publication History
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Published on February 2, 2012
Financial Disclosures
- Dr. David A. Dougan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.