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1. Introduction
2. Mitochondria (ageing and disease)
3. Quality control of mitochondria
4. Mitochondria structure and origin
5. Biogenesis of mitochondrial proteins
6. Mitochondrial protein quality control (mtPQC)
7. Mitochondrial chaperones and proteases
8. Mitochondrial AAA+ proteases
9. Proteotoxic stress
10. Mitochondrial unfolded protein response
11. Proposed model for mtUPR signaling
12. The AAA+ unfoldase: CLPX
13. Substrate recognition and delivery
14. Bacterial ClpXP substrates
15. Mitochondrial CLPX interacting proteins
16. Is PIDP38/CLPM a mitochondrial protein?
17. The E-domain of CLPX
18. CLPX-CLPM complexes occur in vivo
19. CLPM a not a CLPXP substrate
20. CLPM is a CLPX-adaptor protein
21. Domain structure of CLPM
22. CLPM is an adaptor protein of CLPX(P)
23. Thank you

Topics Covered

• Protein homeostasis in mitochondria
• Mitochondria play an important role in ageing and disease
• Quality control of mitochondria is controlled at three different levels
• Protein quality control (PQC) in mitochondria is maintained by mitochondrial chaperones and AAA+ proteases
• Following proteotoxic stress a specific mitochondrial unfolded protein response (mtUPR) is activated
• The AAA+ protease CLPXP is proposed to play a key role in mtUPR signaling
• A novel mtCLPX interacting protein that modulates the activity of mtCLPXP both in vitro and in vivo has been identified

Links

Series:

• Protein Homeostasis

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on February 2, 2012

Financial Disclosures

• Dr. David A. Dougan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.