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- Overview of Chaperone Networks
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1. Mapping the molecular chaperone interaction network in yeast
- Prof. Walid A. Houry
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2. The interaction network of the GroEL chaperonin
- Prof. Dr. F. Ulrich Hartl
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3. Human heat shock protein families
- Prof. Herman Kampinga
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4. Extracellular proteostasis: an emerging field
- Prof. Mark Wilson
- Proteasome Networks
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6. Biogenesis of the eukaryotic proteasome
- Prof. Mark Hochstrasser
- Understanding Intrinsically Disordered Proteins in Protein Homeostasis
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7. Intrinsically unstructured proteins: regulation and disease
- Dr. M. Madan Babu
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8. The roles of intrinsic disorder in protein interaction networks
- Prof. Vladimir N. Uversky
- Gene Regulatory Networks and their Role in Protein Homeostasis
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10. Structure, evolution and dynamics of gene regulatory networks
- Dr. M. Madan Babu
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12. Protein-protein interaction networks
- Prof. Peter Csermely
- Protein Homeostasis in the Endoplasmic Reticulum
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13. Role of calnexin and calreticulin in protein homeostasis within the endoplasmic reticulum
- Prof. David B. Williams
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14. The unfolded protein response
- Prof. Kazutoshi Mori
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15. Role of ER stress in cystic fibrosis airway inflammation
- Dr. Carla Maria Pedrosa Ribeiro
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16. The recognition of misfolded glycoproteins in the endoplasmic reticulum
- Dr. David Y. Thomas
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17. Chaperone systems of the endoplasmic reticulum
- Prof. Linda M. Hendershot
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18. The ERAD network
- Prof. Daniel Hebert
- Protein Homeostasis in the Mitochondria
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19. Protein homeostasis in mitochondria: AAA+ chaperones & proteases
- Dr. David A. Dougan
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21. Mitochondrial chaperonin Hsp60: locations, functions and pathology
- Prof. Francesco Cappello
- Prof. Alberto J. L. Macario
- Protein Homeostasis in the Nucleus
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22. Nuclear protein quality control degradation
- Dr. Richard G. Gardner
- Protein Homeostasis in Aging Disease
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23. Protein homeostasis during ageing: C. elegans as a model organism
- Prof. Nektarios Tavernarakis
- Protein Homeostasis in Neurodegeneration
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24. Endoplasmic reticulum stress in neurodegenerative diseases
- Prof. Claudio Soto
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25. Roles for Hsp40 molecular chaperones in protein misfolding disease
- Prof. Douglas M. Cyr
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26. Protein folding in vivo
- Prof. James Bardwell
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27. Protein degradation and defense against neurodegenerative disease 1
- Prof. Alfred Goldberg
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28. Protein degradation and defense against neurodegenerative disease 2
- Prof. Alfred Goldberg
Printable Handouts
Navigable Slide Index
- Introduction
- Eukaryotic secretory pathway
- Protein folding in the ER
- Protein misfolding in the ER
- ER-associated protein degradation: ERAD
- The steps of ERAD
- Substrate recognition
- BiP recognition and targeting of ERAD substrates
- N-linked glycosylation
- Glycans as sorting signals
- Mannose trimming as an ERAD signal
- S. cerevisiae glycan mediated sorting
- Mannose processing for ERAD (1)
- Yeast ER mannosidases
- Mannose processing for ERAD (2)
- S. cerevisiae ERAD sorting and targeting
- Mammalian ERAD pathway
- Mammalian ER GH47 family members
- EDEM1 complex
- ER MRH domain family members
- Os9 and XTP3-B complexes
- ERAD selection and targeting - yeast-like model
- ERAD selection and targeting: glycan adapter (1)
- ERAD selection and targeting: glycan adapter (2)
- Herp and VIMP ERAD adapter proteins
- Possible ERAD translocons
- Extraction of ERAD substrates
- ER E3 ligases
- ERAD pathways
Topics Covered
- Eukaryotic secretory pathway
- ER processes
- ERAD steps
- Substrate recognition
- Glycans as sorting signals
- Yeast ERAD process
- Mammalian ERAD process
- ERAD adapter proteins
- ERAD translocons
- ERAD E3 ligases
Talk Citation
Hebert, D. (2012, February 2). The ERAD network [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 20, 2025, from https://doi.org/10.69645/TNIK4117.Export Citation (RIS)
Publication History
- Published on February 2, 2012
Financial Disclosures
- Prof. Daniel Hebert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.