• Overview of Chaperone Networks
• 41 min
  1. Mapping the molecular chaperone interaction network in yeast

  • Prof. Walid A. Houry
• 30 min
  2. The interaction network of the GroEL chaperonin

  • Prof. Dr. F. Ulrich Hartl
• 61 min
  3. Human heat shock protein families

  • Prof. Herman Kampinga
• 42 min
  4. Extracellular proteostasis: an emerging field

  • Prof. Mark Wilson
• 36 min
  5. Protein homeostasis and the chaperone interaction network in Arabidopsis thaliana

  • Prof. Rongmin Zhao
• Proteasome Networks
• 64 min
  6. Biogenesis of the eukaryotic proteasome

  • Prof. Mark Hochstrasser
• Understanding Intrinsically Disordered Proteins in Protein Homeostasis
• 36 min
  7. Intrinsically unstructured proteins: regulation and disease

  • Dr. M. Madan Babu
• 43 min
  8. The roles of intrinsic disorder in protein interaction networks

  • Prof. Vladimir N. Uversky
• Gene Regulatory Networks and their Role in Protein Homeostasis
• 38 min
  9. Network motifs: basic building blocks of biological networks

  • Prof. Uri Alon
• 41 min
  10. Structure, evolution and dynamics of gene regulatory networks

  • Dr. M. Madan Babu
• 33 min
  11. Computational methods in analysis of gene regulation and protein interactions

  • Prof. Ron Shamir
• 51 min
  12. Protein-protein interaction networks

  • Prof. Peter Csermely
• Protein Homeostasis in the Endoplasmic Reticulum
• 56 min
  13. Role of calnexin and calreticulin in protein homeostasis within the endoplasmic reticulum

  • Prof. David B. Williams
• 30 min
  14. The unfolded protein response

  • Prof. Kazutoshi Mori
• 38 min
  15. Role of ER stress in cystic fibrosis airway inflammation

  • Dr. Carla Maria Pedrosa Ribeiro
• 57 min
  16. The recognition of misfolded glycoproteins in the endoplasmic reticulum

  • Dr. David Y. Thomas
• 49 min
  17. Chaperone systems of the endoplasmic reticulum

  • Prof. Linda M. Hendershot
• 74 min
  18. The ERAD network

  • Prof. Daniel Hebert
• Protein Homeostasis in the Mitochondria
• 22 min
  19. Protein homeostasis in mitochondria: AAA+ chaperones & proteases

  • Dr. David A. Dougan
• 46 min
  20. Protein homeostasis in mitochondria: chaperones and proteases of the mitochondrial matrix

  • Prof. Wolfgang Voos
• 26 min
  21. Mitochondrial chaperonin Hsp60: locations, functions and pathology

  • Prof. Francesco Cappello
  • Prof. Alberto J. L. Macario
• Protein Homeostasis in the Nucleus
• 23 min
  22. Nuclear protein quality control degradation

  • Dr. Richard G. Gardner
• Protein Homeostasis in Aging Disease
• 27 min
  23. Protein homeostasis during ageing: C. elegans as a model organism

  • Prof. Nektarios Tavernarakis
• Protein Homeostasis in Neurodegeneration
• 41 min
  24. Endoplasmic reticulum stress in neurodegenerative diseases

  • Prof. Claudio Soto
• 48 min
  25. Roles for Hsp40 molecular chaperones in protein misfolding disease

  • Prof. Douglas M. Cyr
• 38 min
  26. Protein folding in vivo

  • Prof. James Bardwell
• 39 min
  27. Protein degradation and defense against neurodegenerative disease 1

  • Prof. Alfred Goldberg
• 42 min
  28. Protein degradation and defense against neurodegenerative disease 2

  • Prof. Alfred Goldberg

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Complex networks are found throughout biology
3. Defining the basic building blocks of networks?
4. Database of transcription interactions in E. coli
5. Algorithm that finds n-node network motifs
6. The thirteen 3-node connected subgraphs
7. The feedforward loop (1)
8. 8 types of FFL regulation sign combinations
9. Only two types of feed-forward loops are significant
10. Dynamics of the feed-forward loop system
11. FFL is a filter
12. GFP reporter plasmid system for promoter activity
13. Construct strains, reporting for a different promoter
14. Each well reports for a different promoter
15. FFL in vivo results
16. Day-day reproducibility of better than 10%
17. Response to brief pulses of X is filtered by FFL
18. Arabinose system FFL
19. Feedforward loop is a sign-sensitive filter
20. Single input module (SIM)
21. Single input module functions
22. Flagella operons are activated in temporal order
23. Arginin biosynthesis system
24. 199 4-node directed connected subgraphs
25. 4-node motifs in E. coli network
26. Dense overlapping regulons (DOR)
27. Mapping logic gates
28. Drawing a complex network (1)
29. Drawing a complex network (2)
30. E. coli and yeast transcriptional networks
31. Incoherent FFL is a pulse generator
32. B. subtilis sporulation
33. FFL drive temporal pattern of pulses
34. Network motifs in human organ development
35. Network motifs in growth factor signaling
36. microRNAs in network motifs
37. Looking for network motifs in other fields
38. Foodwebs have "consensus motifs"
39. Links between WWW pages
40. Reverse engineering of electronic circuit
41. Map of synaptic connections
42. FFL in C. elegans avoidance reflex circuit
43. Summary
44. Acknowledgments

Topics Covered

• Complex networks are found throughout biology
• Can we define the basic building blocks of networks?
• Database of direct transcription interactions in E. coli
• Algorithm that finds n-node network motifs
• Feedforward loop (FFL)
• Dynamics of the feed-forward loop system
• The feed-forward loop is a filter for transient signals allowing fast shutdown
• GFP reporter plasmid system for promoter activity
• Response to brief pulses of X is filtered by FFL
• Sign-sensitive filtering by arabinose feed-forward loop
• Single input module (SIM)
• Dense overlapping regulons (DOR)
• Incoherent FFL is a pulse generator
• Network motifs in human organ development
• Network motifs in growth factor signalling
• High-accuracy promoter activity measurements in living cells

Links

Series:

• Protein Homeostasis

Categories:

• Biochemistry
• Cell Biology
• Methods

Talk Citation

Publication History

• Published on February 2, 2012

Financial Disclosures

• Prof. Uri Alon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.