• Overview of Chaperone Networks
• 41 min
  1. Mapping the molecular chaperone interaction network in yeast

  • Prof. Walid A. Houry
• 30 min
  2. The interaction network of the GroEL chaperonin

  • Prof. Dr. F. Ulrich Hartl
• 61 min
  3. Human heat shock protein families

  • Prof. Herman Kampinga
• 42 min
  4. Extracellular proteostasis: an emerging field

  • Prof. Mark Wilson
• 36 min
  5. Protein homeostasis and the chaperone interaction network in Arabidopsis thaliana

  • Prof. Rongmin Zhao
• Proteasome Networks
• 64 min
  6. Biogenesis of the eukaryotic proteasome

  • Prof. Mark Hochstrasser
• Understanding Intrinsically Disordered Proteins in Protein Homeostasis
• 36 min
  7. Intrinsically unstructured proteins: regulation and disease

  • Dr. M. Madan Babu
• 43 min
  8. The roles of intrinsic disorder in protein interaction networks

  • Prof. Vladimir N. Uversky
• Gene Regulatory Networks and their Role in Protein Homeostasis
• 38 min
  9. Network motifs: basic building blocks of biological networks

  • Prof. Uri Alon
• 41 min
  10. Structure, evolution and dynamics of gene regulatory networks

  • Dr. M. Madan Babu
• 33 min
  11. Computational methods in analysis of gene regulation and protein interactions

  • Prof. Ron Shamir
• 51 min
  12. Protein-protein interaction networks

  • Prof. Peter Csermely
• Protein Homeostasis in the Endoplasmic Reticulum
• 56 min
  13. Role of calnexin and calreticulin in protein homeostasis within the endoplasmic reticulum

  • Prof. David B. Williams
• 30 min
  14. The unfolded protein response

  • Prof. Kazutoshi Mori
• 38 min
  15. Role of ER stress in cystic fibrosis airway inflammation

  • Dr. Carla Maria Pedrosa Ribeiro
• 57 min
  16. The recognition of misfolded glycoproteins in the endoplasmic reticulum

  • Dr. David Y. Thomas
• 49 min
  17. Chaperone systems of the endoplasmic reticulum

  • Prof. Linda M. Hendershot
• 74 min
  18. The ERAD network

  • Prof. Daniel Hebert
• Protein Homeostasis in the Mitochondria
• 22 min
  19. Protein homeostasis in mitochondria: AAA+ chaperones & proteases

  • Dr. David A. Dougan
• 46 min
  20. Protein homeostasis in mitochondria: chaperones and proteases of the mitochondrial matrix

  • Prof. Wolfgang Voos
• 26 min
  21. Mitochondrial chaperonin Hsp60: locations, functions and pathology

  • Prof. Francesco Cappello
  • Prof. Alberto J. L. Macario
• Protein Homeostasis in the Nucleus
• 23 min
  22. Nuclear protein quality control degradation

  • Dr. Richard G. Gardner
• Protein Homeostasis in Aging Disease
• 27 min
  23. Protein homeostasis during ageing: C. elegans as a model organism

  • Prof. Nektarios Tavernarakis
• Protein Homeostasis in Neurodegeneration
• 41 min
  24. Endoplasmic reticulum stress in neurodegenerative diseases

  • Prof. Claudio Soto
• 48 min
  25. Roles for Hsp40 molecular chaperones in protein misfolding disease

  • Prof. Douglas M. Cyr
• 38 min
  26. Protein folding in vivo

  • Prof. James Bardwell
• 39 min
  27. Protein degradation and defense against neurodegenerative disease 1

  • Prof. Alfred Goldberg
• 42 min
  28. Protein degradation and defense against neurodegenerative disease 2

  • Prof. Alfred Goldberg

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. It is important to explore
3. Knowledge of intracellular processes
4. Mechanisms of intracellular proteostasis
5. Coral spawn allusion
6. Knowledge of extracellular processes
7. Importance of extracellular proteostasis
8. Prominent amyloid diseases
9. Other protein aggregation diseases
10. Extracellular refolding
11. Selective extracellular proteolysis
12. Labelling and removal
13. Serendipity is a wonderful thing
14. Clusterin inhibits protein aggregation in stress (1)
15. Clusterin inhibits protein aggregation in stress (2)
16. Clusterin-client protein complexes
17. Identified extracellular chaperones
18. ECs in human plasma
19. Depletion of ECs from plasma
20. Clusterin KO mice
21. Circulating alpha2M and beta2m complexes
22. ECs role in protein aggregation and clearance
23. Structure of alpha2M
24. Protease trapping action of alpha2M
25. Chaperone/protease inhibitor function
26. Hypothetical scheme for in vivo roles of alpha2M
27. Current research foci
28. Radiolabelled clusterin-substrate complexes
29. Biodistribution of complexes in rats
30. Intracellular fate of complexes
31. Inducing shear stress in plasma
32. Fishing for client proteins
33. Endogenous clients for clusterin
34. A model for extracellular proteostasis
35. Motor neuron disease
36. Intracellular protein inclusions
37. Flow cytometry to purify inclusions
38. Collaborators
39. References

Topics Covered

• Extracellular proteostasis
• Mechanisms of intracellular proteostasis
• Disease relevance and potential mechanisms of extracellular proteostasis
• Extracellular chaperones, mechanism and abundance
• Alpha-2-macroglobulin
• Fate of extracellular chaperone-client protein complexes in vivo
• Model of extracellular proteostasis
• Clusterin can also enter the cytosol (Motor neurone disease)

Links

Series:

• Protein Homeostasis

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on February 2, 2012

Financial Disclosures

• Prof. Mark Wilson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.