• View the Talks
• 50 min
  1. Where the thoughts dwell: history of neuroscience and introduction into neuroglia

  • Prof. Alexei Verkhratsky
• 35 min
  2. Astrocytes: definition, appearance and general physiology 1

  • Prof. Alexei Verkhratsky
• 30 min
  3. Astrocytes: definition, appearance and general physiology 2

  • Prof. Alexei Verkhratsky
• 39 min
  4. Glial calcium signalling

  • Prof. Alexei Verkhratsky
• 33 min
  5. Astroglial calcium signalling: what it could tell us

  • Prof. Dmitri Rusakov
• 42 min
  6. Neuronal-glial chemical transmission mediated by glutamate and ATP

  • Prof. Alexei Verkhratsky
• 27 min
  7. Energy and amino acid neurotransmitter metabolism in astrocytes

  • Prof. Helle Waagepetersen
• 49 min
  8. Mechanisms of glutamate release from astrocytes

  • Prof. Vladimir Parpura
• 37 min
  9. Cannabinoid type 1 receptors in astrocytes

  • Prof. Giovanni Marsicano
• 34 min
  10. Neuronal-glial anatomical plasticity in the hypothalamus

  • Dr. Stéphane H.R. Oliet
• 25 min
  11. General physiology of oligodendrocytes

  • Prof. Arthur M. Butt
• 35 min
  12. Neuropathology of microglia and oligodendrocytes

  • Prof. Arthur M. Butt
• 38 min
  13. Oligodendroglia/MCT1 are an unexpected contributor to CNS toxicity/neurodegeneration

  • Prof. Jeffrey D. Rothstein
• 41 min
  14. Physiology and pathophysiology of microglia

  • Prof. Dr. Uwe-Karsten Hanisch
• 39 min
  15. Properties of regulated exocytosis in astrocytes

  • Prof. Robert Zorec
• 49 min
  16. Exocytosis and gliocrine astroglia

  • Prof. Robert Zorec
• 37 min
  17. Noradrenergic hypothesis of neurodegeneration and astroglia

  • Prof. Robert Zorec
• 45 min
  18. Principles of astrogliopathology: from reactivity to atrophy and degeneration

  • Prof. Alexei Verkhratsky
• 23 min
  19. Regulation of synaptic plasticity by astroglia

  • Prof. Dmitri Rusakov
• 48 min
  20. Enteric glia: the glue of the enteric nervous system

  • Dr. Keith A. Sharkey
• 38 min
  21. Purinergic neuron-to-glia signaling in the enteric nervous system

  • Dr. Brian D. Gulbransen
• 43 min
  22. Astrocytes and Alexander disease: the first - but not last - primary astrocyte disease

  • Prof. Albee Messing
• 45 min
  23. Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons

  • Prof. Vladimir Parpura
• 43 min
  24. The impact of astrocyte mitochondrial ATP production on neuroprotection after stroke

  • Prof. James Lechleiter
• 33 min
  25. Hepatic encephalopathy in cirrhosis: a disorder of glial-neuronal signalling

  • Prof. Roger F. Butterworth
• 33 min
  26. Hepatic encephalopathy in acute liver failure: a primary neurogliopathy

  • Prof. Roger F. Butterworth
• 37 min
  27. Bi-directional communication at the neurovascular unit: implications for neuronal function

  • Prof. Jessica A. Filosa
• 51 min
  28. Astrocyte reactivity

  • Prof. Michael Sofroniew
• 36 min
  29. Roles of microglia in the healthy brain

  • Dr. Marie-Ève Tremblay
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  30. Astroglia in neuropathology

  • Prof. Alexei Verkhratsky
• 44 min
  31. Cell biology and physiology of astroglia

  • Prof. Alexei Verkhratsky
• 29 min
  32. General physiology of oligodendrocytes and Schwann cells

  • Prof. Arthur M. Butt

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Astroglia
3. Basic features of passive astrocytes
4. Astrocytes occupy spatially separated domains (1)
5. Astrocytes occupy spatially separated domains (2)
6. Astrocytes occupy spatially separated domains (3)
7. Astrocytes are inter-connected via gap junctions
8. One astrocyte - many neurons, and vice versa
9. Astroglia closely contact synaptic terminals
10. Astrocytes - a revolutionary decade (1)
11. Astrocytes show spontaneous calcium signalling
12. Astrocytes respond to afferent stimulation
13. Astrocyte stimulation triggers glutamate release
14. Calcium elevation in astrocytes
15. Astrocytes - the new concept
16. Astrocyte-neuron signalling: potential concerns
17. Effects of astrocyte endogenous calcium
18. Monitoring astrocyte physiology and signalling
19. How to suppress slow calcium elevations?
20. A candidate (glio)transmitter signal
21. Calcium signalling & NMDAR-dependent LTP
22. Activation of the NMDAR co-agonist site
23. Reducing NMDAR co-agonist site occupancy
24. 750 nM DCKA blocks LTP
25. LTP and the availability of NMDAR co-agonist sites
26. LTP and the supply of D-serine by astrocytes
27. No evidence of D-serine release by astrocytes
28. Astrocytes extend their control of LTP induction (1)
29. Astrocytes extend their control of LTP induction (2)
30. Astrocytes extend their control of LTP induction (3)
31. Tentative mechanisms to extend LTP control
32. Conclusion
33. The task
34. Acknowledgements
35. Thank you for your attention

Topics Covered

• Astroglia are the most abundant type of glial cells
• Their role has recently emerged as an active contributor to neural function
• The underlying mechanisms remain poorly understood
• Astrocytes release D-serine in a Ca2+ dependent manner
• Interference with this release reduces activation of synaptic NMDA receptors
• This in turn could severely impair induction of long-term synaptic potentiation
• Astroglia thus may play a fundamental role in mechanisms of memory formation in the brain

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on January 1, 2012

Financial Disclosures

• Prof. Dmitri Rusakov has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.