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Navigable Slide Index

1. Introduction
2. Review of key ideas from part 1
3. Two-locus Wright-Fisher model (1)
4. Two-locus Wright-Fisher model (2)
5. Ancestral recombination graph (1)
6. Ancestral recombination graph (2)
7. Ancestral recombination graph (3)
8. Ancestral recombination graph (4)
9. Ancestral recombination graph (5)
10. Linkage disequilibrium (LD)
11. Measures of LD: D'
12. Evolution of D'
13. Disease-marker association
14. Measures of LD: r-squared
15. Comparison of D' and r-squared
16. LD due to linkage (1)
17. LD due to linkage (2)
18. LD due to linkage (3)
19. LD and minor allele frequency (1)
20. LD and minor allele frequency (2)
21. LD and minor allele frequency (3)
22. LD due to admixture (1)
23. LD due to admixture (2)
24. LD in human populations
25. Extent and structure of LD
26. Haplotype blocks (1)
27. Haplotype blocks (2)
28. Further reading

Topics Covered

• Overview of part 1
• Two-locus Wright-Fisher model
• Ancestral Recombination Graph (ARG)
• Measures of LD
• Disease-marker association
• LD due to linkage
• LD due to admixture
• Haplotype sharing
• LD in human populations: empirical studies
• Haplotype blocks

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Balding, D. and Morris, A. (2004, September 1). Introduction to population genetics 2: linkage disequilibrium [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/BILM3436.
Export Citation (RIS)

Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. David Balding has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Dr. Andrew Morris has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.