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1. Introduction
2. Ionotropic glutamate receptor subunits
3. Long-term potentiation and long-term depression
4. An excitatory synapse-low frequency transmission
5. AMPARs mediate fast synaptic transmission
6. NMDARs' role in low frequency transmission
7. NMDARs trigger the induction of LTP
8. Synaptic activation of NMDARs
9. NMDARs in Mg2+-free media
10. Dual component EPSCs
11. NMDAR activation in high frequency transmission
12. Regulation of an excitatory synapse (1)
13. GABAA receptor-mediated synaptic inhibition
14. Regulation of an excitatory synapse (2)
15. GABAB autoreceptors regulate synaptic inhibition
16. Regulation of an excitatory synapse (3)
17. GABAB autoreceptors regulate LTP induction
18. NMDARs generate local Ca2+ signal in spines (1)
19. NMDARs generate local Ca2+ signal in spines (2)
20. Ca2+ activates various kinases (including CamKII)
21. Possible loci of expression
22. Alterations in release properties
23. LTP & AMPAR-mediated synaptic transmission
24. LTP & NMDAR-mediated synaptic transmission
25. Increase in AMPAR function in LTP
26. Increase in AMPAR single channel conductance
27. Increase in AMPAR number in LTP
28. NSF stabilises AMPARs & maintains LTP
29. PKMzeta stabilises NSF interaction with AMPARs
30. A summary of NMDAR-LTP mechanisms

Topics Covered

• Synaptic plasticity
• Long-term potentiation (LTP)
• Glutamate receptors
• AMPA and NMDA receptors
• Hippocampus
• Learning & Memory
• Phosphorylation

Links

Series:

• Ion Channels

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Collingridge, G. (2011, October 27). Glutamate receptor modulation and long-term synaptic plasticity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 18, 2019, from https://hstalks.com/bs/2133/.

Publication History

• Published on October 27, 2011

Financial Disclosures

• Prof. Graham Collingridge has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.