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Navigable Slide Index

1. Introduction
2. Edwin Smith surgical papyrus
3. Traumatic Brain Injury (TBI)
4. Heterogeneity of traumatic brain injury
5. Concussion definition (1)
6. Concussion definition (2)
7. Mild TBI a misnomer
8. Recovery from concussion
9. Neurocognitive testing after concussion
10. Brain physiology is related to recovery
11. Post-concussion symptoms
12. Effects of repetitive sports concussion
13. Gender and recovery from mild TBI
14. Gender and more severe TBI
15. Age & recovery from TBI in high school athletes
16. Aging and TBI
17. Chronic neurodegeneration and TBI
18. Chronic neurodegeneration over time - MRI study
19. Complexity of blast effects
20. Statistics: invisible wounds of war
21. Tissue damage mechanisms caused by TBI
22. Pathways of secondary injury in TBI
23. Necrosis vs. apoptosis
24. Two forms of cell death caused by TBI
25. Complex relationships exist in brain after TBI
26. Genomics and CNS injury
27. Changes in gene expression after brain injury
28. CDK inhibitors
29. Flavopiridol effect on brain tissue after TBI (1)
30. Flavopiridol effect on brain tissue after TBI (2)
31. Flavopiridol effect on recovery
32. Gene expression change after injury
33. Microglia associated factors
34. NADPH oxidase is up-regulated following TBI
35. NADPH oxidase inhibition reduces lesion size
36. Comparison of pre-clinical & clinical studies
37. Pre-clinical evaluation design criteria
38. Laser targeted vs. multipotential treatment
39. Multipotential drugs for TBI
40. Multipotential drugs for TBI - in vitro models
41. Genomic changes affected by 35b treatment
42. Effects of treatment with a multipotential drug (1)
43. Effects of treatment with a multipotential drug (2)
44. Improving likelihood of successful clinical trials
45. Summary

Topics Covered

• Heterogeneity of traumatic brain injury
• Concussion
• Mild TBI
• Neurocognitive testing
• Brain physiology is related to recovery
• Post-concussion symptoms
• Effects of repetitive sports concussion
• Gender and recovery
• Age and recovery
• Chronic neurodegeneration
• Complexity of blast effects
• Pathways of secondary injury in TBI
• Genomics and CNS injury
• Recommended design criteria for pre-clinical evaluation of pharmacological agents for TBI
• Laser targeted strategies
• Multipotential treatment
• In vitro models
• Improving likelihood of successful clinical trials

Links

Series:

• Neurotrauma

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Faden, A. (2011, October 27). Traumatic brain injury: from the ball field to the battlefield [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 25, 2023, from https://hstalks.com/bs/2109/.
Export Citation (RIS)

Publication History

• Published on October 27, 2011

Financial Disclosures

• Prof. Alan Faden has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.