• View the Talks
• 50 min
  1. Where the thoughts dwell: history of neuroscience and introduction into neuroglia

  • Prof. Alexei Verkhratsky
• 35 min
  2. Astrocytes: definition, appearance and general physiology 1

  • Prof. Alexei Verkhratsky
• 30 min
  3. Astrocytes: definition, appearance and general physiology 2

  • Prof. Alexei Verkhratsky
• 39 min
  4. Glial calcium signalling

  • Prof. Alexei Verkhratsky
• 33 min
  5. Astroglial calcium signalling: what it could tell us

  • Prof. Dmitri Rusakov
• 42 min
  6. Neuronal-glial chemical transmission mediated by glutamate and ATP

  • Prof. Alexei Verkhratsky
• 27 min
  7. Energy and amino acid neurotransmitter metabolism in astrocytes

  • Prof. Helle Waagepetersen
• 49 min
  8. Mechanisms of glutamate release from astrocytes

  • Prof. Vladimir Parpura
• 37 min
  9. Cannabinoid type 1 receptors in astrocytes

  • Prof. Giovanni Marsicano
• 34 min
  10. Neuronal-glial anatomical plasticity in the hypothalamus

  • Dr. Stéphane H.R. Oliet
• 25 min
  11. General physiology of oligodendrocytes

  • Prof. Arthur M. Butt
• 35 min
  12. Neuropathology of microglia and oligodendrocytes

  • Prof. Arthur M. Butt
• 38 min
  13. Oligodendroglia/MCT1 are an unexpected contributor to CNS toxicity/neurodegeneration

  • Prof. Jeffrey D. Rothstein
• 41 min
  14. Physiology and pathophysiology of microglia

  • Prof. Dr. Uwe-Karsten Hanisch
• 39 min
  15. Properties of regulated exocytosis in astrocytes

  • Prof. Robert Zorec
• 49 min
  16. Exocytosis and gliocrine astroglia

  • Prof. Robert Zorec
• 37 min
  17. Noradrenergic hypothesis of neurodegeneration and astroglia

  • Prof. Robert Zorec
• 45 min
  18. Principles of astrogliopathology: from reactivity to atrophy and degeneration

  • Prof. Alexei Verkhratsky
• 23 min
  19. Regulation of synaptic plasticity by astroglia

  • Prof. Dmitri Rusakov
• 48 min
  20. Enteric glia: the glue of the enteric nervous system

  • Dr. Keith A. Sharkey
• 38 min
  21. Purinergic neuron-to-glia signaling in the enteric nervous system

  • Dr. Brian D. Gulbransen
• 43 min
  22. Astrocytes and Alexander disease: the first - but not last - primary astrocyte disease

  • Prof. Albee Messing
• 45 min
  23. Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons

  • Prof. Vladimir Parpura
• 43 min
  24. The impact of astrocyte mitochondrial ATP production on neuroprotection after stroke

  • Prof. James Lechleiter
• 33 min
  25. Hepatic encephalopathy in cirrhosis: a disorder of glial-neuronal signalling

  • Prof. Roger F. Butterworth
• 33 min
  26. Hepatic encephalopathy in acute liver failure: a primary neurogliopathy

  • Prof. Roger F. Butterworth
• 37 min
  27. Bi-directional communication at the neurovascular unit: implications for neuronal function

  • Prof. Jessica A. Filosa
• 51 min
  28. Astrocyte reactivity

  • Prof. Michael Sofroniew
• 36 min
  29. Roles of microglia in the healthy brain

  • Dr. Marie-Ève Tremblay
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  30. Astroglia in neuropathology

  • Prof. Alexei Verkhratsky
• 44 min
  31. Cell biology and physiology of astroglia

  • Prof. Alexei Verkhratsky
• 29 min
  32. General physiology of oligodendrocytes and Schwann cells

  • Prof. Arthur M. Butt

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Messages
3. Talk outline
4. Exocytosis
5. The forms life
6. Inventions after emergence of eukaryotic cells
7. Development of eumetazoans
8. Neuromuscular junction and secretory organelles
9. Release of neural transmitter substances
10. Classical view of exocytosis in neurons
11. The patch-clamp monitoring
12. The patch-clamp monitoring used on a neuron
13. Fastest rate constant of vesicle fusion in neurons
14. The patch-clamp monitoring used on an astrocyte
15. Microinjection of tetanus toxin to astrocytes
16. Tetanus toxin and vesicle fusion in astrocytes
17. Rate constant of vesicle fusion in astrocytes
18. Regulated exocytosis and gliotransmission
19. Simultaneous measurements of cell swelling
20. Exocytosis in astrocytes
21. Types of vesicles in astrocytes
22. Glutamate (Glu) release from astrocytes
23. Glu release & measurements of NADH and Cm
24. Calcium-dependent release of peptides
25. Peptide-containing vesicles appear to store ATP
26. Studying ATP release from astrocytes
27. Slow transient inward current
28. STICs occur in a calcium-dependent manner
29. Conclusions
30. Acknowledgements

Topics Covered

• Exocytosis
• Exocytosis in evolution
• Exocytosis in astrocytes
• Development of eumetazoans
• Neuromuscular junction and secretory organelles
• The patch-clamp monitoring of membrane capacitance (surface area) in cultured neurones and astrocytes
• Simultaneous measurements of cell swelling by monitoring cell cross section area and membrane capacitance
• Astrocytes exhibit calcium-dependent regulated exocytosis
• Glutamate release from astrocytes
• Calcium-dependent release of peptides

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on June 29, 2011

Financial Disclosures

• There are no commercial/financial disclosures.