Mitochondrial biogenesis and dynamics

In this talk, the focus is mitochondrial biogenesis and dynamics, supported by coverage of the expanded roles of mitochondria beyond energy production, including how mitochondrial biogenesis and dynamics adapt to cellular needs. We will discuss the regulation of mitochondrial formation, mechanisms of fission and fusion, and the importance of maintaining mitochondrial quality through processes like mitophagy. Lecture will also highlight the balance between biogenesis and turnover in cellular health, as well as connections to disease when this balance is disrupted. Finally, we will consider how insights into mitochondrial dynamics may open new avenues for treating disorders linked to mitochondrial dysfunction. Mitochondria are known as the cells powerhouse, but their importance extends far beyond ATP synthesis. These organelles are dynamic, forming interconnected networks that adapt and remodel in response to cellular needs. Mitochondrial biogenesis and dynamics regulate their growth, number, shape, and quality. This lecture will explore the controls of mitochondrial formation, mechanisms of fission and fusion, maintenance of mitochondrial health, adaptation to metabolic demands, and links to disease. Mitochondrial biogenesis is the generation of new mitochondria to meet cellular energy needs, mainly regulated by the transcriptional coactivator PGC one Alpha. PGC one Alpha integrates signals from exercise, cold,