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Topics Covered
- Clinical trial design
- Biostatistics
- Statistical analysis
- Real-world evidence
- Patient-reported outcomes
- Gene therapy
- Regulatory submissions
- Data modelling
Biography
Avery McIntosh, PhD is a Director of Biostatistics at Pfizer, where he works in the Internal Medicine Research Unit. Dr. McIntosh has worked in multiple disease areas, stages of clinical development, and drug modalities. He is a member of the American Statistical Association Cell and Gene Therapy Working Group, and is the Chief Statistical Consultant for Clinical Pharmacology & Therapeutics, the flagship journal of the American Society of Clinical Pharmacology & Therapeutics (ASCPT). Additionally, he is co-author of the invited author textbook Development of Gene Therapies: Strategic, Scientific, Regulatory, and Access Considerations (Taylor & Francis/CRC Press).
Talk Citation
McIntosh, A. (2026, February 26). What I do: director of biostatistics [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2026, from https://doi.org/10.69645/VSOA3525.Export Citation (RIS)
Publication History
- Published on February 26, 2026
Financial Disclosures
- Dr. Avery McIntosh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Pharmaceutical Sciences
Transcript
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0:00
Interviewer: Today, in a series
of interviews on what I do,
I'm interviewing
Dr. Avery McIntosh,
Biostatistician
Director at Pfizer.
On his LinkedIn page,
he has written,
"I have a passion for finding
data-driven solutions
to complex problems."
Dr. McIntosh's research
interests include
trial design and
analysis strategies
for cell and gene therapies,
small sample inference,
and use of real-world evidence
in clinical development.
Dr. McIntosh has experience in
"driving innovative
approaches to develop and
commercialize multiple early
and late-stage programs,
small molecule, antibody, and
gene therapy modalities."
Dr. McIntosh, thank you very
much for sparing the time.
To start to understand
what you do
and how you do it and
with whom it is done,
may I ask two questions?
One, where does the
question you seek to
answer come from?
Do you go out seeking
questions to answer,
or are they brought to you?
Two, who decides if your answer
is correct? Dr. McIntosh.
Dr. McIntosh: Thank you, Neil,
for that nice introduction.
The questions that we, as drug
developers, seek to answer
usually come from a
multi-stakeholder perspective.
We have clinical teams involved
in the development and
potential commercialization
of investigational new drugs
and from my perspective
as a biostatistician,