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Biomedical Basics

Next-generation sequencing (NGS)

  • Created by Henry Stewart Talks
Published on December 31, 2025   4 min

A selection of talks on Infectious Diseases

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This session centers on next generation sequencing, NGS, offering a structured look at the fundamental principles and major technologies behind next generation sequencing, highlighting how it differs from traditional approaches. We will discuss common platforms like lumina, PAC Bio, and Oxford Nanopore, as well as the key laboratory steps involved in sequencing workflows. Applications of NGS in research and clinical settings will be explored, along with an overview of the bioinformatics processes required to analyze sequencing data. Finally, we will address current challenges and the profound impact of NGS on genomics and biomedical science. Next generation sequencing or NGS refers to a set of technologies that enable rapid, high throughput sequencing of DNA and RNA. Unlike traditional SAGA sequencing, which could sequence only one DNA fragment at a time, NGS can generate millions or billions of sequences in parallel. This has greatly increased sequencing speed, reduced costs, and open new possibilities in research and clinical practice, making NGS central to genomics and diverse biological studies. Several NGS technologies are used today, each with distinct chemistry and strengths. The lumina platform is most widely adopted using sequencing by synthesis to generate massive numbers of accurate short reads. Other options like PAC Bio provide long read sequencing, improving assembly and detection of complex variants.

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Next-generation sequencing (NGS)

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