• Co-ordination of G1 Progression
• 37 min
  1. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  2. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  3. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• Chromosome Duplication
• 47 min
  4. Replication licensing

  • Prof. Julian Blow
• 51 min
  5. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  6. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 35 min
  7. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Preparing for Mitosis
• 27 min
  8. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  9. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  10. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• Spindle Assembly and Chromosome Segregation
• 30 min
  11. Bipolar spindle assembly

  • Dr. Eric Karsenti
• 54 min
  12. Chromosome bi-orientation in yeast

  • Prof. Mike Stark
  • Prof. Tomo Tanaka
• 43 min
  13. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• Mitotic Exit and Cytokinesis
• 39 min
  14. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• Checkpoints Governing Cell Cycle Progression
• 34 min
  15. The DNA damage response

  • Dr. Vincenzo Costanzo
• 54 min
  16. The spindle checkpoint

  • Dr. Kevin Hardwick
• 27 min
  17. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  18. The G2/M transition

  • Prof. Dr. René Medema
• The Cell Cycle in Development and Cancer
• 62 min
  19. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 18 min
  20. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  21. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 30 min
  22. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 48 min
  23. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 47 min
  24. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Meiosis: A Specialized Cell Cycle
• 58 min
  25. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  26. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. E2F transcription factors control cell cycle entry
3. E2f controls transcription of cell cycle regulators
4. Inhibitory and mitogenic signals
5. The pocket proteins: pRB family of proteins
6. Differential roles of the pocket proteins (1)
7. Different pocket proteins bind different E2Fs
8. E2F targets regulated by distinct E2F complexes
9. Rb mutant mice
10. Inhibition of E2Fs is key to pRB's activity
11. Differential roles of the pocket proteins (2)
12. E2Fs can induce apoptosis and senescence
13. Role of pRB-E2F in DNA damage response
14. pRB-E2F in DNA damage response - experiment 1
15. pRB-E2F in DNA damage response - experiment 2
16. pRB contributes to activation of apoptosis
17. pRB's apoptosis induction in vivo
18. The pRB/E2F proliferation pathway
19. Mutations in the pRB/E2F pathway (1)
20. Mutations in the pRB/E2F pathway (2)
21. Acknowledgements

Topics Covered

• The E2F transcription factors control cell cycle entry
• The pRB/E2F pathway
• pRB and E2F are both families of proteins
• Differential roles of the pocket proteins
• Repression and activation of E2F target genes is regulated by distinct E2F complexes
• Rb mutant mice
• Inhibition of the activating E2Fs is key to pRB's tumor suppressive activity
• The activating E2Fs can also induce apoptosis and senescence genes in tumor cells
• Role of pRB-E2F in DNA damage response
• pRB contributes to the activation of pro-apoptotic genes in response to DNA damage

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on April 30, 2009
• Archived on May 28, 2025

Financial Disclosures

• Prof. Jacqueline Lees has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.