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1. Introduction
2. Biological roles of lipids
3. Major lipid classes found in the cell
4. The endoplasmic reticulum (ER)
5. Metabolism of lipids in the ER
6. Lipid-metabolizing enzymes found in the ER
7. Maintaining cellular cholesterol homeostasis
8. Activation of gene expression by SREBPs
9. Situations that cause ER stress
10. The unfolded protein response (UPR)
11. Lipid metabolism and the UPR

Topics Covered

• Biological roles of lipids
• Major lipid classes found in the cell
• Metabolism of lipids in the ER
• Examples of lipidmetabolizing enzymes found in the ER
• Strategies for maintaining cellular cholesterol homeostasis
• Activation of gene expression by SREBPs
• Situations that cause ER stress
• The unfolded protein response (UPR) and lipid metabolism

Links

Series:

• The Endoplasmic Reticulum

Categories:

• Cell Biology
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Luis Agellon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.