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1. Introduction
2. Disclosures
3. Chronic migraine
4. Chronic Daily Headache and Evolution of the term Chronic Migraine
5. Chronic daily headache (CDH) (1)
6. Chronic daily headache (CDH) (2)
7. Chronic daily headache (CDH) (3)
8. Evolution of diagnostic terms
9. The 4 types of CDH
10. Transformed migraine (TM)
11. Silberstein-Lipton approach
12. ICHD-1 to ICHD-2
13. ICHD-2 (2004)
14. Problems with ICHD-2 CM
15. MOH and IHCD-2 (2004)
16. The Heisenberg Uncertainty Principle of MOH in ICHD-2
17. ICHD-2 revised CM: A1.5.1 (2006)
18. MOH, revised, ICHD-2 (2005)
19. Revised MOH A8.2 (2006)
20. ICHD-3 definition of CM
21. ICHD-3 criteria for MOH
22. The US FDA cuts the Gordian Knot
23. Other CDH types: CTTH
24. Chronic tension-type headache (CTTH)
25. CM: clinical picture
26. What does CM look like clinically?
27. CM is mostly migraine days
28. Progression to MOH/CM
29. The boundary between EM and CM
30. Are the current definitions of HFEM and CM correct?
31. PRO measurement analysis
32. Imaging does differentiate EM from CM with ICHD3 criteria
33. Extensive imaging studies
34. New proposed CM criteria
35. CM and acute MO
36. Is CM with acute medication overuse secondary or one disorder?
37. Is CM with acute medication overuse different than MOH?
38. Onabot responders
39. Anti-CGRP therapy
40. Eptinezumab conversion from CM with MOH to EM in 3 months
41. Galcanezumab worked equally well in EM and CM with MO
42. Atogepant reduced MMDs WWO MO
43. Changes in EM/CM/MOH diagnoses and treatment paradigm
44. Changes: diagnoses & treatment paradigm
45. One way to put this together
46. Oxygen:fire as CGRP:migraine
47. Conclusions
48. Acknowledgements

Topics Covered

• Chronic migraine
• Chronic Daily Headache (CDH)
• Transformed Migraine (TM)
• Silberstein-Lipton approach
• ICHD-3 Criteria for MOH
• Chronic Tension-Type Headache (CTTH)
• Boundary between CM and EM
• New proposed CM criteria
• Onabot responders
• Anti-CGRP therapy

Links

Series:

• Toward a Deeper Understanding of Headache and Migraine

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on January 31, 2024

Financial Disclosures

• Research funding: Abbvie, Aeon, Amgen, Annovis, Axsome, Cassava, Cognition, Eli Lilly, Inhibikase, Ipsen, Lundbeck, Merz, Neurolief, Pfizer, PrecisionMed, Revance, Scilex, Suven, UCB. Consultant and/or Advisory Boards (honoraria): Abbvie, Aeon, Alphasights, Amgen, Aruene/eNeura, Atheneum, Axsome Therapeutics, Becker Pharmaceutical Consulting, ClearView Healthcare Partners, ClickTherapeutics, CoolTech, CRG, Decision Resources, Defined Health, DRG, Eli Lilly, ExpertConnect, FCB Health, Fenix, GLG, Guidepoint Global, Health Advances, Health Science Communications, HMP Communications, Impel, Initiator Pharma, InteractiveForums, Keyquest, Ki Health Partners, Krog and Partners, Lundbeck, M3 Global Research, Magellan Health, Magnolia Innovation, Miravo Healthcare, MJH Holdings, Neurofront Therapeutics, Neurolief, Nocira, Novartis, P Value Communications, Pain Insights, Inc, Palion Medical, Perfood, Pfizer, Pulmatrix, Putnam Associates, Rehaler, SAI MedPartners, Satsuma, Scilex, Slingshot Insights, Spherix Global Insights, Strategy Inc, Synapse Medical Communication, System Analytic, Taylor and Francis, Tegus, Teva, Theranica, Tonix, Trinity Partners, Unity HA, Vial, XOC. Salary: Dartmouth-Hitchcock Medical Center, Thomas Jefferson University, Ki Health Partners. Speakers Bureau: AbbVie, Eli Lilly, Pfizer, Scilex, Teva. CME honoraria: American Academy of Neurology, American Headache Society, Annenberg Center for Health Sciences, Catamount Medical Education, Diamond Headache Clinic, Forefront Collaborative, Haymarket Medical Education, HMP Global, Medical Education Speakers Network, Medical Learning Institute Peerview, Migraine Association of Ireland, Miller Medical Education, National Association for Continuing Education, North American Center for CME, The Ohio State University, Physicians’ Education Resource, PlatformQ Education, Primed, Vindico Medical Education, WebMD/Medscape.