Registration for a live webinar on 'Innovative Vaccines and Viral Pathogenesis: Insights from Recent Monkeypox Research' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Why we need animal models
- Maximal electroshock seizure (MES) test
- PTZ seizure test
- Discovery of new AEDs
- Models of epilepsy or epileptic seizures
- Models for specific types of epilepsy
- The kindling model of temporal lobe epilepsy
- Anticonvulsant spectrum of AEDs
- Other indications of approved AEDs
- Top 10 therapeutic classes by US sales
- Discovery of new AEDs - conclusions
- Animal testing models and antiepileptic drugs
- Specific models for pharmacoresistant seizures
- Animal models of drug-resistant epilepsy
- AED responders vs. non-responders
- Mechanisms of drug resistance in epilepsy
- The NIH anticonvulsant screening project
- Evaluating changes in new AEDs efficacy
- Efficacy of new AEDs during chronic treatment
- Adverse effects of AED (epileptic/non-epileptic) (1)
- Adverse effects of AED (epileptic/non-epileptic) (2)
- Estimating effective AED plasma concentration (1)
- Estimating effective AED plasma concentration (2)
- Antiepileptogenic/disease-modifying treatments
- Epilepsy development, progression, intervention
- Testing antiepileptogenic drug potential
- Future goals for therapeutic intervention
- Using antiepileptic drugs for antiepileptogenesis
- Therapeutic intervention - rational strategies
- Rational strategies for antiepileptogenesis
- GABA receptors during epileptogenesis-excitatory
- Modification of epileptogenesis by Bumetanide
- Summary
- Acknowledgments
Topics Covered
- Diverse models available
- Invaluable preclinical approach for discovery of new treatments for epilepsy
- Specific models for pharmacoresistant seizures
- Models for the discovery of epilepsy-preventing drugs
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Löscher, W. (2011, July 13). Animal models of seizures and epilepsy [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 12, 2024, from https://doi.org/10.69645/CEEK3533.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Wolfgang Löscher has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.