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Printable Handouts
Navigable Slide Index
- Introduction
- Sir Archibald Garrod
- JBS Haldane
- Examples of diseases
- Metabolism of Dietary Folate
- Conceptual and analytic challenges
- Outline - Designs
- Study designs
- Outline - simple pairwise analyses
- Definition - NOTA BENE
- Example: risk of disease and lof odds of disease
- Different scale gives different in interaction (1)
- Different scale gives different in interaction (2)
- The standard "test for interaction"
- Example: all relationships should be known
- Screening for stratum-specific effects
- Gene associated with risk in any subgroup
- Exposure associated with risk in any genotype
- Example: DNA repair gene XRCC1
- Example: test for genetic effect
- Beyond binary G and E
- Outline - power considerations
- Power
- Programs for power calculations
- Parameters to specify
- Ge_trend example
- Ge_trend example: results
- Ge_trend example: results under minimum power
- Ge_trend example: results under maximum power
- Sample size is necessary to detect genetic effect
- Test for "interaction"
- Screening for genetic effect
- Outline - more sophisticated analyses
- Beyond one gene-one environmental factor
- Ordinal coding
- Ordinal coding - multiple loci
- Ordinal coding - three parameter model
- Hierarchical Models
- Example [Aragaki et al. 1997]
- Machine learning methods
- Relation between training- and test-set error
- Caveat Emptor
- Final Thoughts
- Software
- References (1)
- References (2)
- Acknowledgements
Topics Covered
- Gene-environment interaction in the development of human traits, including disease
- Conceptual and analytical challenges
- Joint analysis of data on both genetic and environmental factors from epidemiologic studies as a way to increase power to detect a polymorphism (or an exposure) that is associated with disease risk
- Study designs
- Statistical modeling issues in the analysis of data
- Sample size and power calculations for a range of designs
- Specification of parameters
- Ordinal coding
- Hierarchical models
- The analysis of highdimensional "pathway" data (multiple related genes and environmental exposures)
Talk Citation
Kraft, P. and Spiegelman, D. (2007, October 1). Statistical issues in epidemiological studies of gene-environment interaction [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/RUNA1690.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Peter Kraft has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Donna Spiegelman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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